diff --git chrome/browser/plugins/plugin_info_host_impl.cc chrome/browser/plugins/plugin_info_host_impl.cc
index f59ecb8fa3246..bb55ea9d91a73 100644
--- chrome/browser/plugins/plugin_info_host_impl.cc
+++ chrome/browser/plugins/plugin_info_host_impl.cc
@@ -142,6 +142,10 @@ bool IsPluginLoadingAccessibleResourceInWebView(
     extensions::ExtensionRegistry* extension_registry,
     int process_id,
     const GURL& resource) {
+  // May be nullptr if using CEF Alloy with extensions disabled.
+  if (!extension_registry)
+    return false;
+
   extensions::WebViewRendererState* renderer_state =
       extensions::WebViewRendererState::GetInstance();
   std::string partition_id;
diff --git chrome/browser/plugins/plugin_utils.cc chrome/browser/plugins/plugin_utils.cc
index 8b3f569882aeb..afc8007a6228b 100644
--- chrome/browser/plugins/plugin_utils.cc
+++ chrome/browser/plugins/plugin_utils.cc
@@ -70,6 +70,13 @@ PluginUtils::GetMimeTypeToExtensionIdMap(
     content::BrowserContext* browser_context) {
   base::flat_map<std::string, std::string> mime_type_to_extension_id_map;
 #if BUILDFLAG(ENABLE_EXTENSIONS)
+  // May be nullptr if using CEF Alloy with extensions disabled.
+  extensions::ExtensionRegistry* registry =
+      extensions::ExtensionRegistry::Get(browser_context);
+  if (!registry) {
+    return mime_type_to_extension_id_map;
+  }
+
   Profile* profile = Profile::FromBrowserContext(browser_context);
   if (extensions::ChromeContentBrowserClientExtensionsPart::
           AreExtensionsDisabledForProfile(profile)) {
@@ -80,9 +87,6 @@ PluginUtils::GetMimeTypeToExtensionIdMap(
       MimeTypesHandler::GetMIMETypeAllowlist();
   // Go through the allowed extensions and try to use them to intercept
   // the URL request.
-  extensions::ExtensionRegistry* registry =
-      extensions::ExtensionRegistry::Get(browser_context);
-  DCHECK(registry);
   for (const std::string& extension_id : allowlist) {
     const extensions::Extension* extension =
         registry->enabled_extensions().GetByID(extension_id);
diff --git chrome/renderer/chrome_content_renderer_client.cc chrome/renderer/chrome_content_renderer_client.cc
index eab276d6ebe23..aa6ca12d1b8bc 100644
--- chrome/renderer/chrome_content_renderer_client.cc
+++ chrome/renderer/chrome_content_renderer_client.cc
@@ -971,6 +971,7 @@ WebPlugin* ChromeContentRendererClient::CreatePlugin(
 
     if ((status == chrome::mojom::PluginStatus::kUnauthorized ||
          status == chrome::mojom::PluginStatus::kBlocked) &&
+        content_settings_agent_delegate &&
         content_settings_agent_delegate->IsPluginTemporarilyAllowed(
             identifier)) {
       status = chrome::mojom::PluginStatus::kAllowed;
@@ -1138,7 +1139,8 @@ WebPlugin* ChromeContentRendererClient::CreatePlugin(
         render_frame->GetRemoteAssociatedInterfaces()->GetInterface(
             plugin_auth_host.BindNewEndpointAndPassReceiver());
         plugin_auth_host->BlockedUnauthorizedPlugin(group_name, identifier);
-        content_settings_agent->DidBlockContentType(content_type);
+        if (content_settings_agent)
+          content_settings_agent->DidBlockContentType(content_type);
         break;
       }
       case chrome::mojom::PluginStatus::kBlocked: {
@@ -1147,7 +1149,8 @@ WebPlugin* ChromeContentRendererClient::CreatePlugin(
             l10n_util::GetStringFUTF16(IDS_PLUGIN_BLOCKED, group_name));
         placeholder->AllowLoading();
         RenderThread::Get()->RecordAction(UserMetricsAction("Plugin_Blocked"));
-        content_settings_agent->DidBlockContentType(content_type);
+        if (content_settings_agent)
+          content_settings_agent->DidBlockContentType(content_type);
         break;
       }
       case chrome::mojom::PluginStatus::kBlockedByPolicy: {
@@ -1157,7 +1160,8 @@ WebPlugin* ChromeContentRendererClient::CreatePlugin(
                                        group_name));
         RenderThread::Get()->RecordAction(
             UserMetricsAction("Plugin_BlockedByPolicy"));
-        content_settings_agent->DidBlockContentType(content_type);
+        if (content_settings_agent)
+          content_settings_agent->DidBlockContentType(content_type);
         break;
       }
     }
diff --git content/browser/browser_plugin/browser_plugin_embedder.h content/browser/browser_plugin/browser_plugin_embedder.h
index ad5f1925735fd..a871f4a7792a7 100644
--- content/browser/browser_plugin/browser_plugin_embedder.h
+++ content/browser/browser_plugin/browser_plugin_embedder.h
@@ -15,6 +15,7 @@
 #define CONTENT_BROWSER_BROWSER_PLUGIN_BROWSER_PLUGIN_EMBEDDER_H_
 
 #include "base/memory/raw_ptr.h"
+#include "content/common/content_export.h"
 
 namespace content {
 
@@ -26,7 +27,7 @@ struct NativeWebKeyboardEvent;
 
 // TODO(wjmaclean): Get rid of "BrowserPlugin" in the name of this class.
 // Perhaps "WebContentsEmbedderDelegate" would be better?
-class BrowserPluginEmbedder {
+class CONTENT_EXPORT BrowserPluginEmbedder {
  public:
   BrowserPluginEmbedder(const BrowserPluginEmbedder&) = delete;
   BrowserPluginEmbedder& operator=(const BrowserPluginEmbedder&) = delete;
diff --git content/browser/browser_plugin/browser_plugin_guest.cc content/browser/browser_plugin/browser_plugin_guest.cc
index a731c5ef5b714..99e313b92c242 100644
--- content/browser/browser_plugin/browser_plugin_guest.cc
+++ content/browser/browser_plugin/browser_plugin_guest.cc
@@ -80,6 +80,8 @@ void BrowserPluginGuest::InitInternal(WebContentsImpl* owner_web_contents) {
       GetWebContents()->GetOrCreateWebPreferences();
   prefs.navigate_on_drag_drop = false;
   GetWebContents()->SetWebPreferences(prefs);
+
+  owner_web_contents_ = owner_web_contents;
 }
 
 BrowserPluginGuest::~BrowserPluginGuest() = default;
diff --git content/browser/browser_plugin/browser_plugin_guest.h content/browser/browser_plugin/browser_plugin_guest.h
index aec6a0eb9cbd0..286e7de6887a7 100644
--- content/browser/browser_plugin/browser_plugin_guest.h
+++ content/browser/browser_plugin/browser_plugin_guest.h
@@ -68,6 +68,8 @@ class BrowserPluginGuest : public WebContentsObserver {
 
   WebContentsImpl* GetWebContents() const;
 
+  WebContentsImpl* owner_web_contents() const { return owner_web_contents_; }
+
  private:
   // BrowserPluginGuest is a WebContentsObserver of |web_contents| and
   // |web_contents| has to stay valid for the lifetime of BrowserPluginGuest.
@@ -77,6 +79,8 @@ class BrowserPluginGuest : public WebContentsObserver {
   void InitInternal(WebContentsImpl* owner_web_contents);
 
   const raw_ptr<BrowserPluginGuestDelegate, DanglingUntriaged> delegate_;
+
+  raw_ptr<WebContentsImpl> owner_web_contents_ = nullptr;
 };
 
 }  // namespace content