diff --git chrome/browser/renderer_preferences_util.cc chrome/browser/renderer_preferences_util.cc
index a0006aa682e7..b83d42c637a6 100644
--- chrome/browser/renderer_preferences_util.cc
+++ chrome/browser/renderer_preferences_util.cc
@@ -35,7 +35,8 @@
 #include "ui/base/cocoa/defaults_utils.h"
 #endif
 
-#if defined(USE_AURA) && (defined(OS_LINUX) || BUILDFLAG(IS_CHROMEOS_LACROS))
+#if defined(USE_AURA) && (defined(OS_LINUX) || BUILDFLAG(IS_CHROMEOS_LACROS)) && \
+    defined(ENABLE_THEMES)
 #include "chrome/browser/themes/theme_service.h"
 #include "chrome/browser/themes/theme_service_factory.h"
 #include "ui/views/linux_ui/linux_ui.h"
@@ -154,7 +155,8 @@ void UpdateFromSystemSettings(blink::RendererPreferences* prefs,
     prefs->caret_blink_interval = interval;
 #endif
 
-#if defined(USE_AURA) && (defined(OS_LINUX) || BUILDFLAG(IS_CHROMEOS_LACROS))
+#if defined(USE_AURA) && (defined(OS_LINUX) || BUILDFLAG(IS_CHROMEOS_LACROS)) && \
+    defined(ENABLE_THEMES)
   views::LinuxUI* linux_ui = views::LinuxUI::instance();
   if (linux_ui) {
     if (ThemeServiceFactory::GetForProfile(profile)->UsingSystemTheme()) {