diff --git chrome/browser/plugins/plugin_info_host_impl.cc chrome/browser/plugins/plugin_info_host_impl.cc
index 484e07af5a98..0e62e20095c7 100644
--- chrome/browser/plugins/plugin_info_host_impl.cc
+++ chrome/browser/plugins/plugin_info_host_impl.cc
@@ -16,6 +16,7 @@
 #include "base/task_runner_util.h"
 #include "base/threading/thread_task_runner_handle.h"
 #include "build/build_config.h"
+#include "cef/libcef/features/features.h"
 #include "chrome/browser/browser_process.h"
 #include "chrome/browser/content_settings/host_content_settings_map_factory.h"
 #include "chrome/browser/plugins/chrome_plugin_service_filter.h"
@@ -53,6 +54,11 @@
 #include "url/gurl.h"
 #include "url/origin.h"
 
+#if BUILDFLAG(ENABLE_CEF)
+#include "cef/libcef/browser/plugins/plugin_service_filter.h"
+#include "cef/libcef/common/extensions/extensions_util.h"
+#endif
+
 #if BUILDFLAG(ENABLE_EXTENSIONS)
 #include "components/guest_view/browser/guest_view_base.h"
 #include "extensions/browser/extension_registry.h"
@@ -74,12 +80,10 @@ namespace {
 class PluginInfoHostImplShutdownNotifierFactory
     : public BrowserContextKeyedServiceShutdownNotifierFactory {
  public:
-  static PluginInfoHostImplShutdownNotifierFactory* GetInstance() {
-    return base::Singleton<PluginInfoHostImplShutdownNotifierFactory>::get();
-  }
+  static PluginInfoHostImplShutdownNotifierFactory* GetInstance();
 
  private:
-  friend struct base::DefaultSingletonTraits<
+  friend struct base::LazyInstanceTraitsBase<
       PluginInfoHostImplShutdownNotifierFactory>;
 
   PluginInfoHostImplShutdownNotifierFactory()
@@ -91,6 +95,16 @@ class PluginInfoHostImplShutdownNotifierFactory
   DISALLOW_COPY_AND_ASSIGN(PluginInfoHostImplShutdownNotifierFactory);
 };
 
+base::LazyInstance<PluginInfoHostImplShutdownNotifierFactory>::Leaky
+    g_plugin_info_host_impl_shutdown_notifier_factory =
+        LAZY_INSTANCE_INITIALIZER;
+
+// static
+PluginInfoHostImplShutdownNotifierFactory*
+PluginInfoHostImplShutdownNotifierFactory::GetInstance() {
+  return g_plugin_info_host_impl_shutdown_notifier_factory.Pointer();
+}
+
 #if BUILDFLAG(ENABLE_EXTENSIONS)
 // Returns whether a request from a plugin to load |resource| from a renderer
 // with process id |process_id| is a request for an internal resource by an app
@@ -99,6 +113,9 @@ bool IsPluginLoadingAccessibleResourceInWebView(
     extensions::ExtensionRegistry* extension_registry,
     int process_id,
     const GURL& resource) {
+  if (!extension_registry)
+    return false;
+
   extensions::WebViewRendererState* renderer_state =
       extensions::WebViewRendererState::GetInstance();
   std::string partition_id;
@@ -128,12 +145,16 @@ bool IsPluginLoadingAccessibleResourceInWebView(
 PluginInfoHostImpl::Context::Context(int render_process_id, Profile* profile)
     : render_process_id_(render_process_id),
       resource_context_(profile->GetResourceContext()),
-#if BUILDFLAG(ENABLE_EXTENSIONS)
-      extension_registry_(extensions::ExtensionRegistry::Get(profile)),
-#endif
       host_content_settings_map_(
           HostContentSettingsMapFactory::GetForProfile(profile)),
       plugin_prefs_(PluginPrefs::GetForProfile(profile)) {
+#if BUILDFLAG(ENABLE_EXTENSIONS)
+#if BUILDFLAG(ENABLE_CEF)
+  if (extensions::ExtensionsEnabled())
+#endif
+    extension_registry_ = extensions::ExtensionRegistry::Get(profile);
+#endif
+
   allow_outdated_plugins_.Init(prefs::kPluginsAllowOutdated,
                                profile->GetPrefs());
   allow_outdated_plugins_.MoveToThread(
@@ -232,6 +253,7 @@ void PluginInfoHostImpl::PluginsLoaded(
         plugin_metadata->identifier(), &output->status);
   }
 
+#if !BUILDFLAG(ENABLE_CEF)
   if (output->status == chrome::mojom::PluginStatus::kNotFound) {
     // Check to see if the component updater can fetch an implementation.
     base::PostTaskAndReplyWithResult(
@@ -243,7 +265,9 @@ void PluginInfoHostImpl::PluginsLoaded(
         base::BindOnce(&PluginInfoHostImpl::ComponentPluginLookupDone, this,
                        params, std::move(output), std::move(callback),
                        std::move(plugin_metadata)));
-  } else {
+  } else
+#endif  // !BUILDFLAG(ENABLE_CEF)
+  {
     GetPluginInfoFinish(params, std::move(output), std::move(callback),
                         std::move(plugin_metadata));
   }
@@ -256,6 +280,14 @@ void PluginInfoHostImpl::Context::DecidePluginStatus(
     PluginMetadata::SecurityStatus security_status,
     const std::string& plugin_identifier,
     chrome::mojom::PluginStatus* status) const {
+#if BUILDFLAG(ENABLE_CEF)
+  // Don't override the user decision.
+  if (*status == chrome::mojom::PluginStatus::kBlocked ||
+      *status == chrome::mojom::PluginStatus::kDisabled) {
+    return;
+  }
+#endif
+
   if (security_status == PluginMetadata::SECURITY_STATUS_FULLY_TRUSTED) {
     *status = chrome::mojom::PluginStatus::kAllowed;
     return;
@@ -380,16 +412,36 @@ bool PluginInfoHostImpl::Context::FindEnabledPlugin(
     return false;
   }
 
+  const bool is_main_frame =
+      main_frame_origin.IsSameOriginWith(url::Origin::Create(url));
+
+#if BUILDFLAG(ENABLE_CEF)
+  CefPluginServiceFilter* filter = static_cast<CefPluginServiceFilter*>(
+      PluginService::GetInstance()->GetFilter());
+  DCHECK(filter);
+
+  size_t i = 0;
+  for (; i < matching_plugins.size(); ++i) {
+    if (filter->IsPluginAvailable(render_process_id_, render_frame_id,
+                                  resource_context_, url, is_main_frame,
+                                  main_frame_origin, &matching_plugins[i],
+                                  status)) {
+      break;
+    }
+  }
+#else  // !BUILDFLAG(ENABLE_CEF)
   content::PluginServiceFilter* filter =
       PluginService::GetInstance()->GetFilter();
   size_t i = 0;
   for (; i < matching_plugins.size(); ++i) {
     if (!filter || filter->IsPluginAvailable(
                        render_process_id_, render_frame_id, resource_context_,
-                       url, main_frame_origin, &matching_plugins[i])) {
+                       url, is_main_frame, main_frame_origin,
+                       &matching_plugins[i])) {
       break;
     }
   }
+#endif  // !BUILDFLAG(ENABLE_CEF)
 
   // If we broke out of the loop, we have found an enabled plugin.
   bool enabled = i < matching_plugins.size();
diff --git chrome/renderer/chrome_content_renderer_client.cc chrome/renderer/chrome_content_renderer_client.cc
index fbf143fd8f32..715b55312e5c 100644
--- chrome/renderer/chrome_content_renderer_client.cc
+++ chrome/renderer/chrome_content_renderer_client.cc
@@ -763,6 +763,7 @@ WebPlugin* ChromeContentRendererClient::CreatePlugin(
 
     if ((status == chrome::mojom::PluginStatus::kUnauthorized ||
          status == chrome::mojom::PluginStatus::kBlocked) &&
+        observer &&
         observer->IsPluginTemporarilyAllowed(identifier)) {
       status = chrome::mojom::PluginStatus::kAllowed;
     }
@@ -950,7 +951,8 @@ WebPlugin* ChromeContentRendererClient::CreatePlugin(
         render_frame->GetRemoteAssociatedInterfaces()->GetInterface(
             &plugin_auth_host);
         plugin_auth_host->BlockedUnauthorizedPlugin(group_name, identifier);
-        observer->DidBlockContentType(content_type, group_name);
+        if (observer)
+          observer->DidBlockContentType(content_type, group_name);
         break;
       }
       case chrome::mojom::PluginStatus::kBlocked: {
@@ -959,7 +961,8 @@ WebPlugin* ChromeContentRendererClient::CreatePlugin(
             l10n_util::GetStringFUTF16(IDS_PLUGIN_BLOCKED, group_name));
         placeholder->AllowLoading();
         RenderThread::Get()->RecordAction(UserMetricsAction("Plugin_Blocked"));
-        observer->DidBlockContentType(content_type, group_name);
+        if (observer)
+          observer->DidBlockContentType(content_type, group_name);
         break;
       }
       case chrome::mojom::PluginStatus::kBlockedByPolicy: {
@@ -969,7 +972,8 @@ WebPlugin* ChromeContentRendererClient::CreatePlugin(
                                        group_name));
         RenderThread::Get()->RecordAction(
             UserMetricsAction("Plugin_BlockedByPolicy"));
-        observer->DidBlockContentType(content_type, group_name);
+        if (observer)
+          observer->DidBlockContentType(content_type, group_name);
         break;
       }
       case chrome::mojom::PluginStatus::kBlockedNoLoading: {
@@ -977,7 +981,8 @@ WebPlugin* ChromeContentRendererClient::CreatePlugin(
             IDR_BLOCKED_PLUGIN_HTML,
             l10n_util::GetStringFUTF16(IDS_PLUGIN_BLOCKED_NO_LOADING,
                                        group_name));
-        observer->DidBlockContentType(content_type, group_name);
+        if (observer)
+          observer->DidBlockContentType(content_type, group_name);
         break;
       }
       case chrome::mojom::PluginStatus::kComponentUpdateRequired: {
diff --git chrome/renderer/plugins/chrome_plugin_placeholder.cc chrome/renderer/plugins/chrome_plugin_placeholder.cc
index 7052b1d68246..ba05a591ebf5 100644
--- chrome/renderer/plugins/chrome_plugin_placeholder.cc
+++ chrome/renderer/plugins/chrome_plugin_placeholder.cc
@@ -350,8 +350,11 @@ void ChromePluginPlaceholder::OnBlockedContent(
 
   if (status ==
       content::RenderFrame::PeripheralContentStatus::CONTENT_STATUS_TINY) {
-    ContentSettingsObserver::Get(render_frame())
-        ->DidBlockContentType(CONTENT_SETTINGS_TYPE_PLUGINS, title_);
+    ContentSettingsObserver* observer =
+        ContentSettingsObserver::Get(render_frame());
+    if (observer) {
+      observer->DidBlockContentType(CONTENT_SETTINGS_TYPE_PLUGINS, title_);
+    }
   }
 
   std::string message = base::StringPrintf(