diff --git chrome/browser/content_settings/host_content_settings_map_factory.cc chrome/browser/content_settings/host_content_settings_map_factory.cc
index 22fdc95ba9c3f..2a0e3cc7f65c8 100644
--- chrome/browser/content_settings/host_content_settings_map_factory.cc
+++ chrome/browser/content_settings/host_content_settings_map_factory.cc
@@ -9,6 +9,7 @@
 #include "base/feature_list.h"
 #include "build/build_config.h"
 #include "build/buildflag.h"
+#include "cef/libcef/features/runtime.h"
 #include "chrome/browser/content_settings/one_time_geolocation_permission_provider.h"
 #include "chrome/browser/permissions/last_tab_standing_tracker_factory.h"
 #include "chrome/browser/profiles/off_the_record_profile_impl.h"
@@ -23,6 +24,10 @@
 #include "extensions/buildflags/buildflags.h"
 #include "ui/webui/webui_allowlist_provider.h"
 
+#if BUILDFLAG(ENABLE_CEF)
+#include "cef/libcef/common/extensions/extensions_util.h"
+#endif
+
 #if BUILDFLAG(ENABLE_EXTENSIONS)
 #include "base/trace_event/trace_event.h"
 #include "chrome/browser/extensions/api/content_settings/content_settings_custom_extension_provider.h"
@@ -55,7 +60,13 @@ HostContentSettingsMapFactory::HostContentSettingsMapFactory()
   DependsOn(SupervisedUserSettingsServiceFactory::GetInstance());
 #endif
 #if BUILDFLAG(ENABLE_EXTENSIONS)
+#if BUILDFLAG(ENABLE_CEF)
+  if (!cef::IsAlloyRuntimeEnabled() || extensions::ExtensionsEnabled()) {
+#endif
   DependsOn(extensions::ContentSettingsService::GetFactoryInstance());
+#if BUILDFLAG(ENABLE_CEF)
+  }
+#endif
 #endif
   // Used by way of ShouldRestoreOldSessionCookies().
 #if BUILDFLAG(ENABLE_SESSION_SERVICE)
@@ -119,6 +130,9 @@ scoped_refptr<RefcountedKeyedService>
   }
 
 #if BUILDFLAG(ENABLE_EXTENSIONS)
+#if BUILDFLAG(ENABLE_CEF)
+  if (!cef::IsAlloyRuntimeEnabled() || extensions::ExtensionsEnabled()) {
+#endif
   // These must be registered before before the HostSettings are passed over to
   // the IOThread.  Simplest to do this on construction.
   settings_map->RegisterProvider(
@@ -131,6 +145,9 @@ scoped_refptr<RefcountedKeyedService>
           // the case where profile->IsOffTheRecord() is true? And what is the
           // interaction with profile->IsGuestSession()?
           false));
+#if BUILDFLAG(ENABLE_CEF)
+  }
+#endif
 #endif // BUILDFLAG(ENABLE_EXTENSIONS)
 #if BUILDFLAG(ENABLE_SUPERVISED_USERS)
   SupervisedUserSettingsService* supervised_service =
diff --git components/content_settings/renderer/content_settings_agent_impl.cc components/content_settings/renderer/content_settings_agent_impl.cc
index f0720efc9e90a..dafbe3e606326 100644
--- components/content_settings/renderer/content_settings_agent_impl.cc
+++ components/content_settings/renderer/content_settings_agent_impl.cc
@@ -167,7 +167,7 @@ ContentSetting GetContentSettingFromRulesImpl(
       return rule.GetContentSetting();
     }
   }
-  NOTREACHED();
+  // NOTREACHED();
   return CONTENT_SETTING_DEFAULT;
 }