diff --git content/browser/renderer_host/render_process_host_impl.cc content/browser/renderer_host/render_process_host_impl.cc
index 83defaaaad55d..76486ceed16e5 100644
--- content/browser/renderer_host/render_process_host_impl.cc
+++ content/browser/renderer_host/render_process_host_impl.cc
@@ -1628,7 +1628,8 @@ bool RenderProcessHostImpl::Init() {
   // initialized because in tests the factory may never have been initialized.
   if (!GetBrowserContext()->IsOffTheRecord() &&
       !base::CommandLine::ForCurrentProcess()->HasSwitch(
-          switches::kDisableGpuShaderDiskCache)) {
+          switches::kDisableGpuShaderDiskCache) &&
+      !storage_partition_impl_->GetPath().empty()) {
     if (auto* cache_factory = GetGpuDiskCacheFactorySingleton()) {
       for (const gpu::GpuDiskCacheType type : gpu::kGpuDiskCacheTypes) {
         auto handle = cache_factory->GetCacheHandle(