diff --git chrome/browser/profiles/off_the_record_profile_impl.cc chrome/browser/profiles/off_the_record_profile_impl.cc
index d153cc5837e0e..5154b21d819ed 100644
--- chrome/browser/profiles/off_the_record_profile_impl.cc
+++ chrome/browser/profiles/off_the_record_profile_impl.cc
@@ -616,7 +616,9 @@ std::unique_ptr<Profile> Profile::CreateOffTheRecordProfile(
 #endif
   if (!profile)
     profile = std::make_unique<OffTheRecordProfileImpl>(parent, otr_profile_id);
-  profile->Init();
+  // With CEF we want to delay initialization.
+  if (!otr_profile_id.IsUniqueForCEF())
+    profile->Init();
   return std::move(profile);
 }
 
diff --git chrome/browser/profiles/profile.cc chrome/browser/profiles/profile.cc
index a3fadab7e4e6b..032300a4c4a0b 100644
--- chrome/browser/profiles/profile.cc
+++ chrome/browser/profiles/profile.cc
@@ -84,6 +84,7 @@ base::LazyInstance<std::set<content::BrowserContext*>>::Leaky
 
 namespace {
 
+const char kCEFOTRProfileIDPrefix[] = "CEF::BrowserContext";
 const char kDevToolsOTRProfileIDPrefix[] = "Devtools::BrowserContext";
 const char kMediaRouterOTRProfileIDPrefix[] = "MediaRouter::Presentation";
 const char kTestOTRProfileIDPrefix[] = "Test::OTR";
@@ -98,6 +99,8 @@ bool Profile::OTRProfileID::AllowsBrowserWindows() const {
   // DevTools::BrowserContext and MediaRouter::Presentation are an
   // exception to this ban.
   return *this == PrimaryID() ||
+         base::StartsWith(profile_id_, kCEFOTRProfileIDPrefix,
+                          base::CompareCase::SENSITIVE) ||
          base::StartsWith(profile_id_, kDevToolsOTRProfileIDPrefix,
                           base::CompareCase::SENSITIVE) ||
          base::StartsWith(profile_id_, kMediaRouterOTRProfileIDPrefix,
@@ -119,6 +122,16 @@ Profile::OTRProfileID Profile::OTRProfileID::CreateUnique(
       base::GUID::GenerateRandomV4().AsLowercaseString().c_str()));
 }
 
+// static
+Profile::OTRProfileID Profile::OTRProfileID::CreateUniqueForCEF() {
+  return CreateUnique(kCEFOTRProfileIDPrefix);
+}
+
+bool Profile::OTRProfileID::IsUniqueForCEF() const {
+  return base::StartsWith(profile_id_, kCEFOTRProfileIDPrefix,
+                          base::CompareCase::SENSITIVE);
+}
+
 // static
 Profile::OTRProfileID Profile::OTRProfileID::CreateUniqueForDevTools() {
   return CreateUnique(kDevToolsOTRProfileIDPrefix);
diff --git chrome/browser/profiles/profile.h chrome/browser/profiles/profile.h
index ca2561e412621..febd52df6c971 100644
--- chrome/browser/profiles/profile.h
+++ chrome/browser/profiles/profile.h
@@ -98,6 +98,10 @@ class Profile : public content::BrowserContext {
     // be applicable to run. Please see crbug.com/1098697#c3 for more details.
     static OTRProfileID CreateUnique(const std::string& profile_id_prefix);
 
+    // Creates a unique OTR profile id to be used for CEF browser contexts.
+    static OTRProfileID CreateUniqueForCEF();
+    bool IsUniqueForCEF() const;
+
     // Creates a unique OTR profile id to be used for DevTools browser contexts.
     static OTRProfileID CreateUniqueForDevTools();
 
@@ -480,6 +484,8 @@ class Profile : public content::BrowserContext {
 
   virtual void RecordPrimaryMainFrameNavigation() = 0;
 
+  void NotifyOffTheRecordProfileCreated(Profile* off_the_record);
+
  protected:
   // Creates an OffTheRecordProfile which points to this Profile.
   static std::unique_ptr<Profile> CreateOffTheRecordProfile(
@@ -491,8 +497,6 @@ class Profile : public content::BrowserContext {
   static PrefStore* CreateExtensionPrefStore(Profile*,
                                              bool incognito_pref_store);
 
-  void NotifyOffTheRecordProfileCreated(Profile* off_the_record);
-
   // Returns whether the user has signed in this profile to an account.
   virtual bool IsSignedIn() = 0;
 
diff --git chrome/browser/profiles/profile_impl.cc chrome/browser/profiles/profile_impl.cc
index 1c79ba2998e34..d0518d23944a7 100644
--- chrome/browser/profiles/profile_impl.cc
+++ chrome/browser/profiles/profile_impl.cc
@@ -998,7 +998,9 @@ Profile* ProfileImpl::GetOffTheRecordProfile(const OTRProfileID& otr_profile_id,
 
   otr_profiles_[otr_profile_id] = std::move(otr_profile);
 
-  NotifyOffTheRecordProfileCreated(raw_otr_profile);
+  // With CEF we want to delay initialization.
+  if (!otr_profile_id.IsUniqueForCEF())
+    NotifyOffTheRecordProfileCreated(raw_otr_profile);
 
   return raw_otr_profile;
 }
diff --git chrome/browser/profiles/profile_manager.cc chrome/browser/profiles/profile_manager.cc
index e443ba3df4107..d3656b3cff757 100644
--- chrome/browser/profiles/profile_manager.cc
+++ chrome/browser/profiles/profile_manager.cc
@@ -496,7 +496,7 @@ ProfileManager::ProfileManager(const base::FilePath& user_data_dir)
                           base::Unretained(this)));
 #endif
 
-  if (ProfileShortcutManager::IsFeatureEnabled() && !user_data_dir_.empty())
+  if (!user_data_dir_.empty() && ProfileShortcutManager::IsFeatureEnabled())
     profile_shortcut_manager_ = ProfileShortcutManager::Create(this);
 
   zombie_metrics_timer_.Start(FROM_HERE, base::Minutes(30), this,
diff --git chrome/browser/profiles/profile_manager.h chrome/browser/profiles/profile_manager.h
index 0719f998c0097..33e392a076183 100644
--- chrome/browser/profiles/profile_manager.h
+++ chrome/browser/profiles/profile_manager.h
@@ -150,7 +150,7 @@ class ProfileManager : public Profile::Delegate {
   // acceptable. Returns null if creation of the new profile fails.
   // TODO(bauerb): Migrate calls from other code to GetProfileByPath(), then
   // make this method private.
-  Profile* GetProfile(const base::FilePath& profile_dir);
+  virtual Profile* GetProfile(const base::FilePath& profile_dir);
 
   // Returns regular or off-the-record profile given its profile key.
   static Profile* GetProfileFromProfileKey(ProfileKey* profile_key);
@@ -182,7 +182,7 @@ class ProfileManager : public Profile::Delegate {
 
   // Returns true if the profile pointer is known to point to an existing
   // profile.
-  bool IsValidProfile(const void* profile);
+  virtual bool IsValidProfile(const void* profile);
 
   // Returns the directory where the first created profile is stored,
   // relative to the user data directory currently in use.
diff --git chrome/browser/profiles/renderer_updater.cc chrome/browser/profiles/renderer_updater.cc
index a2c7b9c45e334..18017a6181a1e 100644
--- chrome/browser/profiles/renderer_updater.cc
+++ chrome/browser/profiles/renderer_updater.cc
@@ -8,6 +8,7 @@
 
 #include "base/bind.h"
 #include "build/chromeos_buildflags.h"
+#include "cef/libcef/features/runtime.h"
 #include "chrome/browser/content_settings/content_settings_manager_delegate.h"
 #include "chrome/browser/content_settings/host_content_settings_map_factory.h"
 #include "chrome/browser/profiles/profile.h"
@@ -60,8 +61,12 @@ void GetGuestViewDefaultContentSettingRules(
 }  // namespace
 
 RendererUpdater::RendererUpdater(Profile* profile) : profile_(profile) {
+  if (cef::IsAlloyRuntimeEnabled()) {
+    identity_manager_ = nullptr;
+  } else {
   identity_manager_ = IdentityManagerFactory::GetForProfile(profile);
   identity_manager_observation_.Observe(identity_manager_.get());
+  }
 #if BUILDFLAG(IS_CHROMEOS_ASH)
   oauth2_login_manager_ =
       ash::OAuth2LoginManagerFactory::GetForProfile(profile_);