diff --git chrome/browser/feedback/system_logs/log_sources/chrome_internal_log_source.cc chrome/browser/feedback/system_logs/log_sources/chrome_internal_log_source.cc
index 05a1108ec2cc..163d2c263155 100644
--- chrome/browser/feedback/system_logs/log_sources/chrome_internal_log_source.cc
+++ chrome/browser/feedback/system_logs/log_sources/chrome_internal_log_source.cc
@@ -18,6 +18,7 @@
 #include "chrome/browser/profiles/profile_manager.h"
 #include "chrome/browser/sync/profile_sync_service_factory.h"
 #include "chrome/common/channel_info.h"
+#include "chrome/common/chrome_switches.h"
 #include "chrome/common/pref_names.h"
 #include "components/browser_sync/profile_sync_service.h"
 #include "components/prefs/pref_service.h"
@@ -266,6 +267,10 @@ void ChromeInternalLogSource::Fetch(SysLogsSourceCallback callback) {
 }
 
 void ChromeInternalLogSource::PopulateSyncLogs(SystemLogsResponse* response) {
+  // CEF should avoid loading ProfileSyncServiceFactory which depends on a lot
+  // of unnecessary Chrome-specific factories.
+  return;
+
   // We are only interested in sync logs for the primary user profile.
   Profile* profile = ProfileManager::GetPrimaryUserProfile();
   if (!profile ||
@@ -309,6 +314,12 @@ void ChromeInternalLogSource::PopulateExtensionInfoLogs(
   if (!profile)
     return;
 
+  // CEF should avoid accessing ExtensionRegistry when extensions are disabled.
+  if (base::CommandLine::ForCurrentProcess()->HasSwitch(
+      switches::kDisableExtensions)) {
+    return;
+  }
+
   extensions::ExtensionRegistry* extension_registry =
       extensions::ExtensionRegistry::Get(profile);
   std::string extensions_list;
diff --git chrome/browser/memory_details.cc chrome/browser/memory_details.cc
index 14b789a35c34..19a1f340a101 100644
--- chrome/browser/memory_details.cc
+++ chrome/browser/memory_details.cc
@@ -17,6 +17,7 @@
 #include "base/task/post_task.h"
 #include "build/build_config.h"
 #include "chrome/browser/profiles/profile.h"
+#include "chrome/common/chrome_switches.h"
 #include "components/nacl/common/nacl_process_type.h"
 #include "components/strings/grit/components_strings.h"
 #include "content/public/browser/browser_child_process_host_iterator.h"
@@ -249,8 +250,11 @@ void MemoryDetails::CollectChildInfoOnUIThread() {
 
 #if BUILDFLAG(ENABLE_EXTENSIONS)
     // Determine if this is an extension process.
+    // CEF should avoid accessing ExtensionRegistry when extensions are disabled.
     bool process_is_for_extensions = false;
-    if (render_process_host) {
+    if (render_process_host &&
+        !base::CommandLine::ForCurrentProcess()->HasSwitch(
+            switches::kDisableExtensions)) {
       content::BrowserContext* context =
           render_process_host->GetBrowserContext();
       extensions::ExtensionRegistry* extension_registry =
diff --git content/browser/resource_context_impl.cc content/browser/resource_context_impl.cc
index 261e9343b8a2..0fe566c705a4 100644
--- content/browser/resource_context_impl.cc
+++ content/browser/resource_context_impl.cc
@@ -56,6 +56,10 @@ URLDataManagerBackend* GetURLDataManagerForResourceContext(
       context->GetUserData(kURLDataManagerBackendKeyName));
 }
 
+const void* GetURLDataManagerBackendUserDataKey() {
+  return kURLDataManagerBackendKeyName;
+}
+
 void InitializeResourceContext(BrowserContext* browser_context) {
   ResourceContext* resource_context = browser_context->GetResourceContext();
 
diff --git content/browser/resource_context_impl.h content/browser/resource_context_impl.h
index 903cc543a242..5bd30ae82974 100644
--- content/browser/resource_context_impl.h
+++ content/browser/resource_context_impl.h
@@ -28,6 +28,8 @@ CONTENT_EXPORT StreamContext* GetStreamContextForResourceContext(
 URLDataManagerBackend* GetURLDataManagerForResourceContext(
     ResourceContext* context);
 
+CONTENT_EXPORT const void* GetURLDataManagerBackendUserDataKey();
+
 // Initialize the above data on the ResourceContext from a given BrowserContext.
 CONTENT_EXPORT void InitializeResourceContext(BrowserContext* browser_context);
 
diff --git content/browser/webui/url_data_manager.cc content/browser/webui/url_data_manager.cc
index a7653565bbf0..7ebf6dd857c9 100644
--- content/browser/webui/url_data_manager.cc
+++ content/browser/webui/url_data_manager.cc
@@ -157,6 +157,11 @@ void URLDataManager::UpdateWebUIDataSource(
       ->UpdateWebUIDataSource(source_name, std::move(update));
 }
 
+// static
+const void* URLDataManager::GetUserDataKey() {
+  return kURLDataManagerKeyName;
+}
+
 // static
 bool URLDataManager::IsScheduledForDeletion(
     const URLDataSourceImpl* data_source) {
diff --git content/browser/webui/url_data_manager.h content/browser/webui/url_data_manager.h
index 95cff69e1b42..7fd849867829 100644
--- content/browser/webui/url_data_manager.h
+++ content/browser/webui/url_data_manager.h
@@ -69,6 +69,8 @@ class CONTENT_EXPORT URLDataManager : public base::SupportsUserData::Data {
       const std::string& source_name,
       std::unique_ptr<base::DictionaryValue> update);
 
+  static const void* GetUserDataKey();
+
  private:
   friend class URLDataSourceImpl;
   friend struct DeleteURLDataSource;