diff --git base/BUILD.gn base/BUILD.gn
index fb85807363f1..bdef6c7f64c7 100644
--- base/BUILD.gn
+++ base/BUILD.gn
@@ -34,6 +34,7 @@ import("//build/config/ui.gni")
 import("//build/nocompile.gni")
 import("//build/timestamp.gni")
 import("//build_overrides/build.gni")
+import("//cef/libcef/features/features.gni")
 import("//testing/libfuzzer/fuzzer_test.gni")
 import("//testing/test.gni")
 import("//third_party/icu/config.gni")
@@ -1634,7 +1635,11 @@ jumbo_component("base") {
     "hash/md5_constexpr_internal.h",
     "hash/sha1.h",
   ]
-  if (is_nacl) {
+  deps += [ "//cef/libcef/features" ]
+  if (enable_cef) {
+    configs += [ "//cef/libcef/features:config" ]
+  }
+  if (is_nacl || is_cef_sandbox_build) {
     sources += [
       "hash/md5_nacl.cc",
       "hash/md5_nacl.h",
diff --git base/hash/md5.h base/hash/md5.h
index 8a49f08dcb04..2f03d7a6d1b3 100644
--- base/hash/md5.h
+++ base/hash/md5.h
@@ -10,8 +10,9 @@
 #include "base/base_export.h"
 #include "base/strings/string_piece.h"
 #include "build/build_config.h"
+#include "cef/libcef/features/features.h"
 
-#if defined(OS_NACL)
+#if defined(OS_NACL) || BUILDFLAG(IS_CEF_SANDBOX_BUILD)
 #include "base/hash/md5_nacl.h"
 #else
 #include "base/hash/md5_boringssl.h"