diff --git chrome/browser/extensions/api/chrome_extensions_api_client.cc chrome/browser/extensions/api/chrome_extensions_api_client.cc
index 399d2720023c5..32755b74185cb 100644
--- chrome/browser/extensions/api/chrome_extensions_api_client.cc
+++ chrome/browser/extensions/api/chrome_extensions_api_client.cc
@@ -13,6 +13,7 @@
 #include "base/strings/string_util.h"
 #include "build/build_config.h"
 #include "build/chromeos_buildflags.h"
+#include "cef/libcef/features/runtime.h"
 #include "chrome/browser/extensions/api/automation_internal/chrome_automation_internal_api_delegate.h"
 #include "chrome/browser/extensions/api/chrome_device_permissions_prompt.h"
 #include "chrome/browser/extensions/api/declarative_content/chrome_content_rules_registry.h"
@@ -84,6 +85,10 @@
 #include "chrome/browser/extensions/clipboard_extension_helper_chromeos.h"
 #endif
 
+#if BUILDFLAG(ENABLE_CEF)
+#include "cef/libcef/browser/chrome/extensions/chrome_mime_handler_view_guest_delegate_cef.h"
+#endif
+
 #if BUILDFLAG(ENABLE_PDF)
 #include "chrome/browser/ui/pdf/chrome_pdf_web_contents_helper_client.h"
 #include "components/pdf/browser/pdf_web_contents_helper.h"
@@ -306,6 +311,11 @@ ChromeExtensionsAPIClient::CreateGuestViewManagerDelegate() const {
 std::unique_ptr<MimeHandlerViewGuestDelegate>
 ChromeExtensionsAPIClient::CreateMimeHandlerViewGuestDelegate(
     MimeHandlerViewGuest* guest) const {
+#if BUILDFLAG(ENABLE_CEF)
+  if (cef::IsChromeRuntimeEnabled()) {
+    return std::make_unique<ChromeMimeHandlerViewGuestDelegateCef>(guest);
+  }
+#endif
   return std::make_unique<ChromeMimeHandlerViewGuestDelegate>();
 }