diff --git chrome/browser/feedback/system_logs/log_sources/chrome_internal_log_source.cc chrome/browser/feedback/system_logs/log_sources/chrome_internal_log_source.cc
index 0aae647fea27f..295319c17b46f 100644
--- chrome/browser/feedback/system_logs/log_sources/chrome_internal_log_source.cc
+++ chrome/browser/feedback/system_logs/log_sources/chrome_internal_log_source.cc
@@ -19,10 +19,12 @@
 #include "base/strings/stringprintf.h"
 #include "base/system/sys_info.h"
 #include "base/task/thread_pool.h"
+#include "base/threading/thread_restrictions.h"
 #include "base/time/time.h"
 #include "build/branding_buildflags.h"
 #include "build/build_config.h"
 #include "build/chromeos_buildflags.h"
+#include "cef/libcef/features/runtime.h"
 #include "chrome/browser/browser_process.h"
 #include "chrome/browser/extensions/chrome_content_browser_client_extensions_part.h"
 #include "chrome/browser/google/google_brand.h"
@@ -397,7 +399,11 @@ void ChromeInternalLogSource::Fetch(SysLogsSourceCallback callback) {
   response->emplace(kOsVersionTag, os_version);
 #endif
 
-  PopulateSyncLogs(response.get());
+  if (!cef::IsAlloyRuntimeEnabled()) {
+    // Avoid loading ProfileSyncServiceFactory which depends on a lot of
+    // unnecessary Chrome-specific factories.
+    PopulateSyncLogs(response.get());
+  }
   PopulateExtensionInfoLogs(response.get());
   PopulatePowerApiLogs(response.get());
 #if BUILDFLAG(IS_WIN)
@@ -471,8 +477,12 @@ void ChromeInternalLogSource::PopulateExtensionInfoLogs(
   if (!profile)
     return;
 
+  // May be nullptr if using CEF Alloy with extensions disabled.
   extensions::ExtensionRegistry* extension_registry =
       extensions::ExtensionRegistry::Get(profile);
+  if (!extension_registry)
+    return;
+
   std::string extensions_list;
   for (const scoped_refptr<const extensions::Extension>& extension :
        extension_registry->enabled_extensions()) {
@@ -576,6 +586,8 @@ void ChromeInternalLogSource::PopulateOnboardingTime(
 #if BUILDFLAG(IS_WIN)
 void ChromeInternalLogSource::PopulateUsbKeyboardDetected(
     SystemLogsResponse* response) {
+  // The below call may result in some DLLs being loaded.
+  base::ScopedAllowBlockingForTesting allow_blocking;
   std::string reason;
   bool result =
       base::win::IsKeyboardPresentOnSlate(ui::GetHiddenWindow(), &reason);
diff --git chrome/browser/memory_details.cc chrome/browser/memory_details.cc
index 2565fae8b1433..9ca16abf99c92 100644
--- chrome/browser/memory_details.cc
+++ chrome/browser/memory_details.cc
@@ -294,8 +294,11 @@ void MemoryDetails::CollectChildInfoOnUIThread() {
     if (render_process_host) {
       content::BrowserContext* context =
           render_process_host->GetBrowserContext();
+
+      // May be nullptr if using CEF Alloy with extensions disabled.
       extensions::ExtensionRegistry* extension_registry =
           extensions::ExtensionRegistry::Get(context);
+      if (extension_registry) {
       extension_set = &extension_registry->enabled_extensions();
       extensions::ProcessMap* process_map =
           extensions::ProcessMap::Get(context);
@@ -311,6 +314,7 @@ void MemoryDetails::CollectChildInfoOnUIThread() {
           break;
         }
       }
+      }
     }
 #endif