diff --git gpu/ipc/service/gpu_memory_buffer_factory_dxgi.cc gpu/ipc/service/gpu_memory_buffer_factory_dxgi.cc
index 2096591596a26..5a0c3fd16eecf 100644
--- gpu/ipc/service/gpu_memory_buffer_factory_dxgi.cc
+++ gpu/ipc/service/gpu_memory_buffer_factory_dxgi.cc
@@ -179,7 +179,8 @@ gfx::GpuMemoryBufferHandle GpuMemoryBufferFactoryDXGI::CreateGpuMemoryBuffer(
   // so make sure that the usage is one that we support.
   DCHECK(usage == gfx::BufferUsage::GPU_READ ||
          usage == gfx::BufferUsage::SCANOUT ||
-         usage == gfx::BufferUsage::SCANOUT_CPU_READ_WRITE)
+         usage == gfx::BufferUsage::SCANOUT_CPU_READ_WRITE ||
+         usage == gfx::BufferUsage::SCANOUT_VEA_CPU_READ)
       << "Incorrect usage, usage=" << gfx::BufferUsageToString(usage);
 
   D3D11_TEXTURE2D_DESC desc = {
@@ -193,7 +194,9 @@ gfx::GpuMemoryBufferHandle GpuMemoryBufferFactoryDXGI::CreateGpuMemoryBuffer(
       D3D11_BIND_SHADER_RESOURCE | D3D11_BIND_RENDER_TARGET,
       0,
       D3D11_RESOURCE_MISC_SHARED_NTHANDLE |
-          D3D11_RESOURCE_MISC_SHARED_KEYEDMUTEX};
+          static_cast<UINT>(usage == gfx::BufferUsage::SCANOUT_VEA_CPU_READ
+               ? D3D11_RESOURCE_MISC_SHARED
+               : D3D11_RESOURCE_MISC_SHARED_KEYEDMUTEX)};
 
   Microsoft::WRL::ComPtr<ID3D11Texture2D> d3d11_texture;
 
diff --git media/video/renderable_gpu_memory_buffer_video_frame_pool.cc media/video/renderable_gpu_memory_buffer_video_frame_pool.cc
index cf5bde2e431fd..51552841427c8 100644
--- media/video/renderable_gpu_memory_buffer_video_frame_pool.cc
+++ media/video/renderable_gpu_memory_buffer_video_frame_pool.cc
@@ -205,7 +205,7 @@ gfx::Size GetBufferSizeInPixelsForVideoPixelFormat(
 bool FrameResources::Initialize() {
   auto* context = pool_->GetContext();
 
-  constexpr gfx::BufferUsage kBufferUsage =
+  gfx::BufferUsage buffer_usage =
 #if BUILDFLAG(IS_MAC) || BUILDFLAG(IS_CHROMEOS)
       gfx::BufferUsage::SCANOUT_VEA_CPU_READ
 #else
@@ -219,6 +219,23 @@ bool FrameResources::Initialize() {
   const gfx::Size buffer_size_in_pixels =
       GetBufferSizeInPixelsForVideoPixelFormat(format_, coded_size_);
 
+#if BUILDFLAG(IS_WIN)
+  // For CEF OSR feature, currently there's no other place in chromium use RGBA.
+  // If the format is RGBA, currently CEF do not write to the texture anymore
+  // once the GMB is returned from CopyRequest. So there will be no race
+  // condition on that texture. We can request a GMB without a keyed mutex to
+  // accelerate and probably prevent some driver deadlock.
+  if (format_ == PIXEL_FORMAT_ARGB || format_ == PIXEL_FORMAT_ABGR) {
+    // This value is 'borrowed', SCANOUT_VEA_CPU_READ is probably invalid
+    // cause there's no real SCANOUT on Windows. We simply use this enum as a
+    // flag to disable mutex in the GMBFactoryDXGI because this enum is also
+    // used above in macOS and CrOS for similar usage (claim no other one will
+    // concurrently use the resource).
+    // https://chromium-review.googlesource.com/c/chromium/src/+/5302103
+    buffer_usage = gfx::BufferUsage::SCANOUT_VEA_CPU_READ;
+  }
+#endif
+
   // Create the GpuMemoryBuffer if MappableSharedImages is not enabled. When its
   // enabled, clients only create a mappable shared image directly without
   // needing to create a GMB.
@@ -226,16 +243,16 @@ bool FrameResources::Initialize() {
       kUseMappableSIForRenderableGpuMemoryBufferVideoFramePool);
   if (!is_mappable_si_enabled) {
     gpu_memory_buffer_ = context->CreateGpuMemoryBuffer(
-        buffer_size_in_pixels, buffer_format, kBufferUsage);
+        buffer_size_in_pixels, buffer_format, buffer_usage);
     if (!gpu_memory_buffer_) {
       LOG(ERROR) << "Failed to allocate GpuMemoryBuffer for frame: coded_size="
                  << coded_size_.ToString()
-                 << ", usage=" << static_cast<int>(kBufferUsage);
+                 << ", usage=" << static_cast<int>(buffer_usage);
       return false;
     }
 
 #if BUILDFLAG(IS_MAC)
-  gpu_memory_buffer_->SetColorSpace(color_space_);
+    gpu_memory_buffer_->SetColorSpace(color_space_);
 #endif
   }
 
@@ -264,7 +281,7 @@ bool FrameResources::Initialize() {
 
   if (is_mappable_si_enabled) {
     shared_image_ = context->CreateSharedImage(
-        buffer_size_in_pixels, kBufferUsage, si_format, color_space_,
+        buffer_size_in_pixels, buffer_usage, si_format, color_space_,
         kTopLeft_GrSurfaceOrigin, kPremul_SkAlphaType, kSharedImageUsage,
         sync_token_);
   } else {