diff --git gpu/ipc/service/gpu_memory_buffer_factory_dxgi.cc gpu/ipc/service/gpu_memory_buffer_factory_dxgi.cc
index 9cac49288f3b1..3ee5ff8714824 100644
--- gpu/ipc/service/gpu_memory_buffer_factory_dxgi.cc
+++ gpu/ipc/service/gpu_memory_buffer_factory_dxgi.cc
@@ -180,7 +180,8 @@ gfx::GpuMemoryBufferHandle GpuMemoryBufferFactoryDXGI::CreateGpuMemoryBuffer(
   // so make sure that the usage is one that we support.
   DCHECK(usage == gfx::BufferUsage::GPU_READ ||
          usage == gfx::BufferUsage::SCANOUT ||
-         usage == gfx::BufferUsage::SCANOUT_CPU_READ_WRITE)
+         usage == gfx::BufferUsage::SCANOUT_CPU_READ_WRITE ||
+         usage == gfx::BufferUsage::SCANOUT_VEA_CPU_READ)
       << "Incorrect usage, usage=" << gfx::BufferUsageToString(usage);
 
   D3D11_TEXTURE2D_DESC desc = {
@@ -194,7 +195,9 @@ gfx::GpuMemoryBufferHandle GpuMemoryBufferFactoryDXGI::CreateGpuMemoryBuffer(
       D3D11_BIND_SHADER_RESOURCE | D3D11_BIND_RENDER_TARGET,
       0,
       D3D11_RESOURCE_MISC_SHARED_NTHANDLE |
-          D3D11_RESOURCE_MISC_SHARED_KEYEDMUTEX};
+          static_cast<UINT>(usage == gfx::BufferUsage::SCANOUT_VEA_CPU_READ
+               ? D3D11_RESOURCE_MISC_SHARED
+               : D3D11_RESOURCE_MISC_SHARED_KEYEDMUTEX)};
 
   Microsoft::WRL::ComPtr<ID3D11Texture2D> d3d11_texture;
 
diff --git media/video/renderable_gpu_memory_buffer_video_frame_pool.cc media/video/renderable_gpu_memory_buffer_video_frame_pool.cc
index b420e7f14165f..83f09abff7173 100644
--- media/video/renderable_gpu_memory_buffer_video_frame_pool.cc
+++ media/video/renderable_gpu_memory_buffer_video_frame_pool.cc
@@ -195,7 +195,7 @@ gfx::Size GetBufferSizeInPixelsForVideoPixelFormat(
 bool FrameResources::Initialize() {
   auto* context = pool_->GetContext();
 
-  constexpr gfx::BufferUsage kBufferUsage =
+  gfx::BufferUsage buffer_usage =
 #if BUILDFLAG(IS_MAC) || BUILDFLAG(IS_CHROMEOS)
       gfx::BufferUsage::SCANOUT_VEA_CPU_READ
 #else
@@ -209,13 +209,30 @@ bool FrameResources::Initialize() {
   const gfx::Size buffer_size_in_pixels =
       GetBufferSizeInPixelsForVideoPixelFormat(format_, coded_size_);
 
+#if BUILDFLAG(IS_WIN)
+  // For CEF OSR feature, currently there's no other place in chromium use RGBA.
+  // If the format is RGBA, currently CEF do not write to the texture anymore
+  // once the GMB is returned from CopyRequest. So there will be no race
+  // condition on that texture. We can request a GMB without a keyed mutex to
+  // accelerate and probably prevent some driver deadlock.
+  if (format_ == PIXEL_FORMAT_ARGB || format_ == PIXEL_FORMAT_ABGR) {
+    // This value is 'borrowed', SCANOUT_VEA_CPU_READ is probably invalid
+    // cause there's no real SCANOUT on Windows. We simply use this enum as a
+    // flag to disable mutex in the GMBFactoryDXGI because this enum is also
+    // used above in macOS and CrOS for similar usage (claim no other one will
+    // concurrently use the resource).
+    // https://chromium-review.googlesource.com/c/chromium/src/+/5302103
+    buffer_usage = gfx::BufferUsage::SCANOUT_VEA_CPU_READ;
+  }
+#endif
+
   // Create the GpuMemoryBuffer.
   gpu_memory_buffer_ = context->CreateGpuMemoryBuffer(
-      buffer_size_in_pixels, buffer_format, kBufferUsage);
+      buffer_size_in_pixels, buffer_format, buffer_usage);
   if (!gpu_memory_buffer_) {
     DLOG(ERROR) << "Failed to allocate GpuMemoryBuffer for frame: coded_size="
                 << coded_size_.ToString()
-                << ", usage=" << static_cast<int>(kBufferUsage);
+                << ", usage=" << static_cast<int>(buffer_usage);
     return false;
   }