diff --git chrome/app/chrome_main_delegate.cc chrome/app/chrome_main_delegate.cc
index 73b6ab0934b14..26f9334cdb668 100644
--- chrome/app/chrome_main_delegate.cc
+++ chrome/app/chrome_main_delegate.cc
@@ -41,6 +41,7 @@
 #include "base/trace_event/trace_event_impl.h"
 #include "build/build_config.h"
 #include "build/chromeos_buildflags.h"
+#include "cef/libcef/features/runtime.h"
 #include "chrome/browser/buildflags.h"
 #include "chrome/browser/chrome_content_browser_client.h"
 #include "chrome/browser/chrome_resource_bundle_helper.h"
@@ -613,6 +614,9 @@ struct MainFunction {
 
 // Initializes the user data dir. Must be called before InitializeLocalState().
 void InitializeUserDataDir(base::CommandLine* command_line) {
+  if (cef::IsChromeRuntimeEnabled()) {
+    return;
+  }
 #if BUILDFLAG(IS_CHROMEOS_LACROS)
   // In debug builds of Lacros, we keep track of when the user data dir
   // is initialized, to ensure the cryptohome is not accessed before login
@@ -853,6 +857,10 @@ ChromeMainDelegate::~ChromeMainDelegate() {
 ChromeMainDelegate::~ChromeMainDelegate() = default;
 #endif  // !BUILDFLAG(IS_ANDROID)
 
+void ChromeMainDelegate::CleanupOnUIThread() {
+  memory_system_.reset();
+}
+
 std::optional<int> ChromeMainDelegate::PostEarlyInitialization(
     InvokedIn invoked_in) {
   DUMP_WILL_BE_CHECK(base::ThreadPoolInstance::Get());
@@ -878,7 +886,7 @@ std::optional<int> ChromeMainDelegate::PostEarlyInitialization(
     // future session's metrics.
     DeferBrowserMetrics(user_data_dir);
 
-#if BUILDFLAG(IS_WIN)
+#if BUILDFLAG(IS_WIN) && !BUILDFLAG(ENABLE_CEF)
     // In the case the process is not the singleton process, the uninstall tasks
     // need to be executed here. A window will be displayed asking to close all
     // running instances.
@@ -1049,7 +1057,8 @@ std::optional<int> ChromeMainDelegate::PostEarlyInitialization(
 
   if (base::FeatureList::IsEnabled(
           features::kWriteBasicSystemProfileToPersistentHistogramsFile)) {
-    bool record = true;
+    // Avoid CEF crash with multi-threaded-message-loop.
+    bool record = !cef::IsChromeRuntimeEnabled();
 #if BUILDFLAG(IS_ANDROID)
     record =
         base::FeatureList::IsEnabled(chrome::android::kUmaBackgroundSessions);
@@ -1520,6 +1529,7 @@ void ChromeMainDelegate::PreSandboxStartup() {
   std::string process_type =
       command_line.GetSwitchValueASCII(switches::kProcessType);
 
+  if (!cef::IsChromeRuntimeEnabled()) {
   crash_reporter::InitializeCrashKeys();
 
 #if BUILDFLAG(IS_CHROMEOS_LACROS)
@@ -1538,6 +1548,7 @@ void ChromeMainDelegate::PreSandboxStartup() {
   InitMacCrashReporter(command_line, process_type);
   SetUpInstallerPreferences(command_line);
 #endif
+  }  // !cef::IsChromeRuntimeEnabled()
 
 #if BUILDFLAG(IS_WIN)
   child_process_logging::Init();
@@ -1750,6 +1761,7 @@ void ChromeMainDelegate::PreSandboxStartup() {
     CHECK(!loaded_locale.empty()) << "Locale could not be found for " << locale;
   }
 
+  if (!cef::IsChromeRuntimeEnabled()) {
 #if BUILDFLAG(IS_POSIX) && !BUILDFLAG(IS_MAC)
   // Zygote needs to call InitCrashReporter() in RunZygote().
   if (process_type != switches::kZygoteProcess) {
@@ -1785,6 +1797,7 @@ void ChromeMainDelegate::PreSandboxStartup() {
   // After all the platform Breakpads have been initialized, store the command
   // line for crash reporting.
   crash_keys::SetCrashKeysFromCommandLine(command_line);
+  }  // !cef::IsChromeRuntimeEnabled()
 
 #if BUILDFLAG(ENABLE_PDF)
   MaybePatchGdiGetFontData();
@@ -1910,6 +1923,7 @@ void ChromeMainDelegate::ZygoteForked() {
     SetUpProfilingShutdownHandler();
   }
 
+  if (!cef::IsChromeRuntimeEnabled()) {
   // Needs to be called after we have chrome::DIR_USER_DATA.  BrowserMain sets
   // this up for the browser process in a different manner.
   const base::CommandLine* command_line =
@@ -1922,6 +1936,7 @@ void ChromeMainDelegate::ZygoteForked() {
 
   // Reset the command line for the newly spawned process.
   crash_keys::SetCrashKeysFromCommandLine(*command_line);
+  }  // !cef::IsChromeRuntimeEnabled()
 }
 
 #endif  // BUILDFLAG(IS_LINUX) || BUILDFLAG(IS_CHROMEOS)
@@ -2021,6 +2036,7 @@ void ChromeMainDelegate::InitializeMemorySystem() {
                               channel == version_info::Channel::DEV);
   const bool gwp_asan_boost_sampling = is_canary_dev || is_browser_process;
 
+  memory_system_ = std::make_unique<memory_system::MemorySystem>();
   memory_system::Initializer()
       .SetGwpAsanParameters(gwp_asan_boost_sampling, process_type)
       .SetProfilingClientParameters(channel,
@@ -2030,5 +2046,5 @@ void ChromeMainDelegate::InitializeMemorySystem() {
                                memory_system::DispatcherParameters::
                                    AllocationTraceRecorderInclusion::kDynamic,
                                process_type)
-      .Initialize(memory_system_);
+      .Initialize(*memory_system_);
 }
diff --git chrome/app/chrome_main_delegate.h chrome/app/chrome_main_delegate.h
index 3553377e96017..5207128b768f2 100644
--- chrome/app/chrome_main_delegate.h
+++ chrome/app/chrome_main_delegate.h
@@ -49,6 +49,8 @@ class ChromeMainDelegate : public content::ContentMainDelegate {
 
   ~ChromeMainDelegate() override;
 
+  virtual void CleanupOnUIThread();
+
  protected:
   // content::ContentMainDelegate:
   std::optional<int> BasicStartupComplete() override;
@@ -98,7 +100,7 @@ class ChromeMainDelegate : public content::ContentMainDelegate {
 
   ChromeContentClient chrome_content_client_;
 
-  memory_system::MemorySystem memory_system_;
+  std::unique_ptr<memory_system::MemorySystem> memory_system_;
 
 #if BUILDFLAG(IS_CHROMEOS_LACROS)
   std::unique_ptr<chromeos::LacrosService> lacros_service_;
diff --git chrome/browser/chrome_browser_main.cc chrome/browser/chrome_browser_main.cc
index 1d9bfb1c1d651..6a016c5d55b1e 100644
--- chrome/browser/chrome_browser_main.cc
+++ chrome/browser/chrome_browser_main.cc
@@ -52,6 +52,7 @@
 #include "build/build_config.h"
 #include "build/chromeos_buildflags.h"
 #include "cc/base/switches.h"
+#include "cef/libcef/features/runtime.h"
 #include "chrome/browser/about_flags.h"
 #include "chrome/browser/active_use_util.h"
 #include "chrome/browser/after_startup_task_utils.h"
@@ -513,7 +514,7 @@ void ProcessSingletonNotificationCallbackImpl(
     return;
   }
 
-#if BUILDFLAG(IS_WIN)
+#if BUILDFLAG(IS_WIN) && !BUILDFLAG(ENABLE_CEF)
   // The uninstall command-line switch is handled by the origin process; see
   // ChromeMainDelegate::PostEarlyInitialization(...). The other process won't
   // be able to become the singleton process and will display a window asking
@@ -816,7 +817,7 @@ int ChromeBrowserMainParts::PreEarlyInitialization() {
     return content::RESULT_CODE_NORMAL_EXIT;
   }
 
-#if BUILDFLAG(IS_WIN)
+#if BUILDFLAG(IS_WIN) && !BUILDFLAG(ENABLE_CEF)
   // If we are running stale binaries then relaunch and exit immediately.
   if (upgrade_util::IsRunningOldChrome()) {
     if (!upgrade_util::RelaunchChromeBrowser(
@@ -829,7 +830,7 @@ int ChromeBrowserMainParts::PreEarlyInitialization() {
     // result in browser startup bailing.
     return chrome::RESULT_CODE_NORMAL_EXIT_UPGRADE_RELAUNCHED;
   }
-#endif  // BUILDFLAG(IS_WIN)
+#endif  // BUILDFLAG(IS_WIN) && !BUILDFLAG(ENABLE_CEF)
 
   return load_local_state_result;
 }
@@ -935,7 +936,7 @@ int ChromeBrowserMainParts::OnLocalStateLoaded(
       browser_process_->local_state());
   platform_management_service->RefreshCache(base::NullCallback());
 
-#if BUILDFLAG(IS_WIN)
+#if BUILDFLAG(IS_WIN) && !BUILDFLAG(ENABLE_CEF)
   if (first_run::IsChromeFirstRun()) {
     bool stats_default;
     if (GoogleUpdateSettings::GetCollectStatsConsentDefault(&stats_default)) {
@@ -948,7 +949,7 @@ int ChromeBrowserMainParts::OnLocalStateLoaded(
                         : metrics::EnableMetricsDefault::OPT_IN);
     }
   }
-#endif  // BUILDFLAG(IS_WIN)
+#endif  // BUILDFLAG(IS_WIN) && !BUILDFLAG(ENABLE_CEF)
 
   std::string locale =
       startup_data_->chrome_feature_list_creator()->actual_locale();
@@ -981,6 +982,7 @@ int ChromeBrowserMainParts::ApplyFirstRunPrefs() {
 #if !BUILDFLAG(IS_ANDROID) && !BUILDFLAG(IS_CHROMEOS_ASH)
   master_prefs_ = std::make_unique<first_run::MasterPrefs>();
 
+#if !BUILDFLAG(ENABLE_CEF)
   std::unique_ptr<installer::InitialPreferences> installer_initial_prefs =
       startup_data_->chrome_feature_list_creator()->TakeInitialPrefs();
   if (!installer_initial_prefs)
@@ -1014,6 +1016,7 @@ int ChromeBrowserMainParts::ApplyFirstRunPrefs() {
                             master_prefs_->confirm_to_quit);
   }
 #endif  // BUILDFLAG(IS_MAC)
+#endif  // !BUILDFLAG(ENABLE_CEF)
 #endif  // !BUILDFLAG(IS_ANDROID) && !BUILDFLAG(IS_CHROMEOS_ASH)
   return content::RESULT_CODE_NORMAL_EXIT;
 }
@@ -1080,6 +1083,7 @@ int ChromeBrowserMainParts::PreCreateThreadsImpl() {
 
   browser_process_->browser_policy_connector()->OnResourceBundleCreated();
 
+#if !BUILDFLAG(ENABLE_CEF)
 // Android does first run in Java instead of native.
 // Chrome OS has its own out-of-box-experience code.
 #if !BUILDFLAG(IS_ANDROID) && !BUILDFLAG(IS_CHROMEOS_ASH)
@@ -1101,6 +1105,7 @@ int ChromeBrowserMainParts::PreCreateThreadsImpl() {
 #endif  // BUILDFLAG(IS_MAC) || BUILDFLAG(IS_LINUX) || BUILDFLAG(IS_CHROMEOS)
   }
 #endif  // !BUILDFLAG(IS_ANDROID) && !BUILDFLAG(IS_CHROMEOS_ASH)
+#endif  // !BUILDFLAG(ENABLE_CEF)
 
 #if BUILDFLAG(IS_MAC)
 #if defined(ARCH_CPU_X86_64)
@@ -1463,6 +1468,7 @@ int ChromeBrowserMainParts::PreMainMessageLoopRunImpl() {
   browser_process_->PreMainMessageLoopRun();
 
 #if BUILDFLAG(IS_WIN)
+#if !BUILDFLAG(ENABLE_CEF)
   // If the command line specifies 'uninstall' then we need to work here
   // unless we detect another chrome browser running.
   if (base::CommandLine::ForCurrentProcess()->HasSwitch(switches::kUninstall)) {
@@ -1474,6 +1480,7 @@ int ChromeBrowserMainParts::PreMainMessageLoopRunImpl() {
     return ChromeBrowserMainPartsWin::HandleIconsCommands(
         *base::CommandLine::ForCurrentProcess());
   }
+#endif  // !BUILDFLAG(ENABLE_CEF)
 
   ui::SelectFileDialog::SetFactory(
       std::make_unique<ChromeSelectFileDialogFactory>());
@@ -1499,6 +1506,7 @@ int ChromeBrowserMainParts::PreMainMessageLoopRunImpl() {
   }
 #endif  // BUILDFLAG(CHROME_FOR_TESTING)
 
+#if !BUILDFLAG(ENABLE_CEF)
   if (base::CommandLine::ForCurrentProcess()->HasSwitch(
           switches::kMakeDefaultBrowser)) {
     bool is_managed = g_browser_process->local_state()->IsManagedPreference(
@@ -1512,18 +1520,22 @@ int ChromeBrowserMainParts::PreMainMessageLoopRunImpl() {
                ? static_cast<int>(content::RESULT_CODE_NORMAL_EXIT)
                : static_cast<int>(chrome::RESULT_CODE_SHELL_INTEGRATION_FAILED);
   }
+#endif  // !BUILDFLAG(ENABLE_CEF)
 
 #if defined(USE_AURA)
   // Make sure aura::Env has been initialized.
   CHECK(aura::Env::GetInstance());
 #endif  // defined(USE_AURA)
 
+
+#if !BUILDFLAG(ENABLE_CEF)
 #if BUILDFLAG(IS_WIN)
   // We must call DoUpgradeTasks now that we own the browser singleton to
   // finish upgrade tasks (swap) and relaunch if necessary.
   if (upgrade_util::DoUpgradeTasks(*base::CommandLine::ForCurrentProcess()))
     return chrome::RESULT_CODE_NORMAL_EXIT_UPGRADE_RELAUNCHED;
 #endif  // BUILDFLAG(IS_WIN)
+#endif  // !BUILDFLAG(ENABLE_CEF)
 
 #if !BUILDFLAG(IS_ANDROID) && BUILDFLAG(ENABLE_DOWNGRADE_PROCESSING)
   // Begin relaunch processing immediately if User Data migration is required
@@ -1562,7 +1574,7 @@ int ChromeBrowserMainParts::PreMainMessageLoopRunImpl() {
   }
 #endif  // !BUILDFLAG(IS_ANDROID) && !BUILDFLAG(IS_CHROMEOS)
 
-#if BUILDFLAG(IS_WIN)
+#if BUILDFLAG(IS_WIN) && !BUILDFLAG(ENABLE_CEF)
   // Check if there is any machine level Chrome installed on the current
   // machine. If yes and the current Chrome process is user level, we do not
   // allow the user level Chrome to run. So we notify the user and uninstall
@@ -1571,7 +1583,7 @@ int ChromeBrowserMainParts::PreMainMessageLoopRunImpl() {
   // obtained but before potentially creating the first run sentinel).
   if (ChromeBrowserMainPartsWin::CheckMachineLevelInstall())
     return chrome::RESULT_CODE_MACHINE_LEVEL_INSTALL_EXISTS;
-#endif  // BUILDFLAG(IS_WIN)
+#endif  // BUILDFLAG(IS_WIN) && !BUILDFLAG(ENABLE_CEF)
 
   // Desktop construction occurs here, (required before profile creation).
   PreProfileInit();
@@ -1614,12 +1626,14 @@ int ChromeBrowserMainParts::PreMainMessageLoopRunImpl() {
         browser_process_->local_state());
   }
 
+#if !BUILDFLAG(ENABLE_CEF)
   // Needs to be done before PostProfileInit, since login manager on CrOS is
   // called inside PostProfileInit.
   content::WebUIControllerFactory::RegisterFactory(
       ChromeWebUIControllerFactory::GetInstance());
   RegisterChromeWebUIConfigs();
   RegisterChromeUntrustedWebUIConfigs();
+#endif
 
 #if BUILDFLAG(IS_ANDROID)
   page_info::SetPageInfoClient(new ChromePageInfoClient());
@@ -1646,6 +1660,7 @@ int ChromeBrowserMainParts::PreMainMessageLoopRunImpl() {
   // Call `PostProfileInit()`and set it up for profiles created later.
   profile_init_manager_ = std::make_unique<ProfileInitManager>(this, profile);
 
+#if !BUILDFLAG(ENABLE_CEF)
 #if !BUILDFLAG(IS_ANDROID) && !BUILDFLAG(IS_CHROMEOS_ASH)
   // Execute first run specific code after the PrefService has been initialized
   // and preferences have been registered since some of the import code depends
@@ -1685,6 +1700,7 @@ int ChromeBrowserMainParts::PreMainMessageLoopRunImpl() {
         *base::CommandLine::ForCurrentProcess());
   }
 #endif  // BUILDFLAG(IS_WIN)
+#endif  // !BUILDFLAG(ENABLE_CEF)
 
   // Configure modules that need access to resources.
   net::NetModule::SetResourceProvider(ChromeNetResourceProvider);
@@ -1770,6 +1786,11 @@ int ChromeBrowserMainParts::PreMainMessageLoopRunImpl() {
         g_browser_process->profile_manager()->GetLastOpenedProfiles();
   }
 #endif  // BUILDFLAG(IS_CHROMEOS_ASH)
+
+  // Bypass StartupBrowserCreator and RunLoop creation with CEF.
+  // CEF with the Chrome runtime will create and manage its own RunLoop.
+#if !BUILDFLAG(ENABLE_CEF)
+
   // This step is costly.
   if (browser_creator_->Start(*base::CommandLine::ForCurrentProcess(),
                               base::FilePath(), profile_info,
@@ -1802,11 +1823,14 @@ int ChromeBrowserMainParts::PreMainMessageLoopRunImpl() {
 
     // Create the RunLoop for MainMessageLoopRun() to use and transfer
     // ownership of the browser's lifetime to the BrowserProcess.
+    // CEF with the Chrome runtime will create and manage its own RunLoop.
     DCHECK(!GetMainRunLoopInstance());
     GetMainRunLoopInstance() = std::make_unique<base::RunLoop>();
     browser_process_->SetQuitClosure(
         GetMainRunLoopInstance()->QuitWhenIdleClosure());
   }
+#endif  // !BUILDFLAG(ENABLE_CEF)
+
   browser_creator_.reset();
 #endif  // !BUILDFLAG(IS_ANDROID)
 
diff --git chrome/browser/chrome_browser_main_mac.mm chrome/browser/chrome_browser_main_mac.mm
index 2f0fe9d22667c..f50fe7bf75df3 100644
--- chrome/browser/chrome_browser_main_mac.mm
+++ chrome/browser/chrome_browser_main_mac.mm
@@ -16,6 +16,7 @@
 #include "base/path_service.h"
 #include "base/strings/sys_string_conversions.h"
 #include "build/branding_buildflags.h"
+#include "cef/libcef/features/features.h"
 #import "chrome/browser/app_controller_mac.h"
 #include "chrome/browser/apps/app_shim/app_shim_listener.h"
 #include "chrome/browser/browser_process.h"
@@ -105,6 +106,7 @@ void ChromeBrowserMainPartsMac::PreCreateMainMessageLoop() {
   }
 #endif  // !BUILDFLAG(CHROME_FOR_TESTING)
 
+#if !BUILDFLAG(ENABLE_CEF)
   // Create the app delegate by requesting the shared AppController.
   CHECK_EQ(nil, NSApp.delegate);
   AppController* app_controller = AppController.sharedController;
@@ -113,6 +115,7 @@ void ChromeBrowserMainPartsMac::PreCreateMainMessageLoop() {
   chrome::BuildMainMenu(NSApp, app_controller,
                         l10n_util::GetStringUTF16(IDS_PRODUCT_NAME), false);
   [app_controller mainMenuCreated];
+#endif  // BUILDFLAG(ENABLE_CEF)
 
   ui::WarmScreenCapture();
 
@@ -152,5 +155,7 @@ void ChromeBrowserMainPartsMac::PostProfileInit(Profile* profile,
 }
 
 void ChromeBrowserMainPartsMac::DidEndMainMessageLoop() {
+#if !BUILDFLAG(ENABLE_CEF)
   [AppController.sharedController didEndMainMessageLoop];
+#endif
 }
diff --git chrome/browser/chrome_content_browser_client.cc chrome/browser/chrome_content_browser_client.cc
index 66b50cf0fd99b..f2e2cc47a513e 100644
--- chrome/browser/chrome_content_browser_client.cc
+++ chrome/browser/chrome_content_browser_client.cc
@@ -47,6 +47,7 @@
 #include "build/build_config.h"
 #include "build/chromeos_buildflags.h"
 #include "build/config/chromebox_for_meetings/buildflags.h"  // PLATFORM_CFM
+#include "cef/libcef/features/features.h"
 #include "chrome/browser/after_startup_task_utils.h"
 #include "chrome/browser/app_mode/app_mode_utils.h"
 #include "chrome/browser/bluetooth/chrome_bluetooth_delegate_impl_client.h"
@@ -1423,6 +1424,8 @@ ChromeContentBrowserClient::GetPopupNavigationDelegateFactoryForTesting() {
 }
 
 ChromeContentBrowserClient::ChromeContentBrowserClient() {
+  keepalive_timer_.reset(new base::OneShotTimer());
+
 #if BUILDFLAG(ENABLE_PLUGINS)
   extra_parts_.push_back(
       std::make_unique<ChromeContentBrowserClientPluginsPart>());
@@ -1460,6 +1463,11 @@ ChromeContentBrowserClient::~ChromeContentBrowserClient() {
   }
 }
 
+void ChromeContentBrowserClient::CleanupOnUIThread() {
+  DCHECK_CURRENTLY_ON(content::BrowserThread::UI);
+  keepalive_timer_.reset();
+}
+
 // static
 void ChromeContentBrowserClient::RegisterLocalStatePrefs(
     PrefRegistrySimple* registry) {
@@ -4375,9 +4383,11 @@ void ChromeContentBrowserClient::BrowserURLHandlerCreated(
                           &search::HandleNewTabURLReverseRewrite);
 #endif  // BUILDFLAG(IS_ANDROID)
 
+#if !BUILDFLAG(ENABLE_CEF)
   // chrome: & friends.
   handler->AddHandlerPair(&ChromeContentBrowserClient::HandleWebUI,
                           &ChromeContentBrowserClient::HandleWebUIReverse);
+#endif
 }
 
 base::FilePath ChromeContentBrowserClient::GetDefaultDownloadDirectory() {
@@ -6484,7 +6494,7 @@ void ChromeContentBrowserClient::OnNetworkServiceCreated(
 #endif
 }
 
-void ChromeContentBrowserClient::ConfigureNetworkContextParams(
+bool ChromeContentBrowserClient::ConfigureNetworkContextParams(
     content::BrowserContext* context,
     bool in_memory,
     const base::FilePath& relative_partition_path,
@@ -6502,6 +6512,8 @@ void ChromeContentBrowserClient::ConfigureNetworkContextParams(
     network_context_params->user_agent = GetUserAgentBasedOnPolicy(context);
     network_context_params->accept_language = GetApplicationLocale();
   }
+
+  return true;
 }
 
 std::vector<base::FilePath>
@@ -7627,10 +7639,10 @@ void ChromeContentBrowserClient::OnKeepaliveRequestStarted(
   const auto now = base::TimeTicks::Now();
   const auto timeout = GetKeepaliveTimerTimeout(context);
   keepalive_deadline_ = std::max(keepalive_deadline_, now + timeout);
-  if (keepalive_deadline_ > now && !keepalive_timer_.IsRunning()) {
+  if (keepalive_deadline_ > now && !keepalive_timer_->IsRunning()) {
     DVLOG(1) << "Starting a keepalive timer(" << timeout.InSecondsF()
              << " seconds)";
-    keepalive_timer_.Start(
+    keepalive_timer_->Start(
         FROM_HERE, keepalive_deadline_ - now,
         base::BindOnce(
             &ChromeContentBrowserClient::OnKeepaliveTimerFired,
@@ -7649,7 +7661,8 @@ void ChromeContentBrowserClient::OnKeepaliveRequestFinished() {
   --num_keepalive_requests_;
   if (num_keepalive_requests_ == 0) {
     DVLOG(1) << "Stopping the keepalive timer";
-    keepalive_timer_.Stop();
+    if (keepalive_timer_)
+      keepalive_timer_->Stop();
     // This deletes the keep alive handle attached to the timer function and
     // unblock the shutdown sequence.
   }
@@ -7789,7 +7802,7 @@ void ChromeContentBrowserClient::OnKeepaliveTimerFired(
   const auto now = base::TimeTicks::Now();
   const auto then = keepalive_deadline_;
   if (now < then) {
-    keepalive_timer_.Start(
+    keepalive_timer_->Start(
         FROM_HERE, then - now,
         base::BindOnce(&ChromeContentBrowserClient::OnKeepaliveTimerFired,
                        weak_factory_.GetWeakPtr(),
diff --git chrome/browser/chrome_content_browser_client.h chrome/browser/chrome_content_browser_client.h
index d8f6e1ea5f843..27172c75e4c3a 100644
--- chrome/browser/chrome_content_browser_client.h
+++ chrome/browser/chrome_content_browser_client.h
@@ -144,6 +144,8 @@ class ChromeContentBrowserClient : public content::ContentBrowserClient {
 
   ~ChromeContentBrowserClient() override;
 
+  virtual void CleanupOnUIThread();
+
   // TODO(https://crbug.com/787567): This file is about calls from content/ out
   // to chrome/ to get values or notify about events, but both of these
   // functions are from chrome/ to chrome/ and don't involve content/ at all.
@@ -681,7 +683,7 @@ class ChromeContentBrowserClient : public content::ContentBrowserClient {
       override;
   void OnNetworkServiceCreated(
       network::mojom::NetworkService* network_service) override;
-  void ConfigureNetworkContextParams(
+  bool ConfigureNetworkContextParams(
       content::BrowserContext* context,
       bool in_memory,
       const base::FilePath& relative_partition_path,
@@ -1184,7 +1186,7 @@ class ChromeContentBrowserClient : public content::ContentBrowserClient {
 
 #if !BUILDFLAG(IS_ANDROID)
   uint64_t num_keepalive_requests_ = 0;
-  base::OneShotTimer keepalive_timer_;
+  std::unique_ptr<base::OneShotTimer> keepalive_timer_;
   base::TimeTicks keepalive_deadline_;
 #endif
 
diff --git chrome/browser/prefs/browser_prefs.cc chrome/browser/prefs/browser_prefs.cc
index 5eef5cdedda4c..d0c16b6d70585 100644
--- chrome/browser/prefs/browser_prefs.cc
+++ chrome/browser/prefs/browser_prefs.cc
@@ -16,6 +16,7 @@
 #include "build/build_config.h"
 #include "build/chromecast_buildflags.h"
 #include "build/chromeos_buildflags.h"
+#include "cef/libcef/features/features.h"
 #include "chrome/browser/about_flags.h"
 #include "chrome/browser/accessibility/accessibility_labels_service.h"
 #include "chrome/browser/accessibility/invert_bubble_prefs.h"
@@ -195,6 +196,10 @@
 #include "chrome/browser/background/background_mode_manager.h"
 #endif
 
+#if BUILDFLAG(ENABLE_CEF)
+#include "cef/libcef/browser/prefs/browser_prefs.h"
+#endif
+
 #if BUILDFLAG(ENABLE_EXTENSIONS)
 #include "chrome/browser/accessibility/animation_policy_prefs.h"
 #include "chrome/browser/apps/platform_apps/shortcut_manager.h"
@@ -1679,7 +1684,8 @@ void RegisterLocalState(PrefRegistrySimple* registry) {
 #endif  // BUILDFLAG(GOOGLE_CHROME_BRANDING)
 #endif  // BUILDFLAG(IS_WIN)
 
-#if !BUILDFLAG(IS_ANDROID) && !BUILDFLAG(IS_CHROMEOS)
+#if !BUILDFLAG(IS_ANDROID) && !BUILDFLAG(IS_CHROMEOS) && \
+    BUILDFLAG(ENABLE_DOWNGRADE_PROCESSING)
   downgrade::RegisterPrefs(registry);
 #endif
 
@@ -1711,6 +1717,11 @@ void RegisterLocalState(PrefRegistrySimple* registry) {
 
   // This is intentionally last.
   RegisterLocalStatePrefsForMigration(registry);
+
+#if BUILDFLAG(ENABLE_CEF)
+  // Always call this last.
+  browser_prefs::RegisterLocalStatePrefs(registry);
+#endif
 }
 
 // Register prefs applicable to all profiles.
@@ -2145,6 +2156,10 @@ void RegisterUserProfilePrefs(user_prefs::PrefRegistrySyncable* registry,
                               const std::string& locale) {
   RegisterProfilePrefs(registry, locale);
 
+#if BUILDFLAG(ENABLE_CEF)
+  browser_prefs::RegisterProfilePrefs(registry);
+#endif
+
 #if BUILDFLAG(IS_ANDROID)
   ::android::RegisterUserProfilePrefs(registry);
 #endif