diff --git chrome/browser/plugins/plugin_info_host_impl.cc chrome/browser/plugins/plugin_info_host_impl.cc
index 1afbaf86ac40..e2edec854ca7 100644
--- chrome/browser/plugins/plugin_info_host_impl.cc
+++ chrome/browser/plugins/plugin_info_host_impl.cc
@@ -18,6 +18,7 @@
 #include "base/task_runner_util.h"
 #include "base/threading/thread_task_runner_handle.h"
 #include "build/build_config.h"
+#include "cef/libcef/features/features.h"
 #include "chrome/browser/browser_process.h"
 #include "chrome/browser/content_settings/host_content_settings_map_factory.h"
 #include "chrome/browser/plugins/chrome_plugin_service_filter.h"
@@ -56,6 +57,11 @@
 #include "url/origin.h"
 #include "widevine_cdm_version.h"  // In SHARED_INTERMEDIATE_DIR.
 
+#if BUILDFLAG(ENABLE_CEF)
+#include "cef/libcef/browser/plugins/plugin_service_filter.h"
+#include "cef/libcef/common/extensions/extensions_util.h"
+#endif
+
 #if BUILDFLAG(ENABLE_EXTENSIONS)
 #include "components/guest_view/browser/guest_view_base.h"
 #include "extensions/browser/extension_registry.h"
@@ -77,12 +83,10 @@ namespace {
 class ShutdownNotifierFactory
     : public BrowserContextKeyedServiceShutdownNotifierFactory {
  public:
-  static ShutdownNotifierFactory* GetInstance() {
-    return base::Singleton<ShutdownNotifierFactory>::get();
-  }
+  static ShutdownNotifierFactory* GetInstance();
 
  private:
-  friend struct base::DefaultSingletonTraits<ShutdownNotifierFactory>;
+  friend struct base::LazyInstanceTraitsBase<ShutdownNotifierFactory>;
 
   ShutdownNotifierFactory()
       : BrowserContextKeyedServiceShutdownNotifierFactory(
@@ -93,6 +97,14 @@ class ShutdownNotifierFactory
   DISALLOW_COPY_AND_ASSIGN(ShutdownNotifierFactory);
 };
 
+base::LazyInstance<ShutdownNotifierFactory>::Leaky g_shutdown_notifier_factory =
+    LAZY_INSTANCE_INITIALIZER;
+
+// static
+ShutdownNotifierFactory* ShutdownNotifierFactory::GetInstance() {
+  return g_shutdown_notifier_factory.Pointer();
+}
+
 #if BUILDFLAG(ENABLE_LIBRARY_CDMS)
 
 enum PluginAvailabilityStatusForUMA {
@@ -124,6 +136,9 @@ bool IsPluginLoadingAccessibleResourceInWebView(
     extensions::ExtensionRegistry* extension_registry,
     int process_id,
     const GURL& resource) {
+  if (!extension_registry)
+    return false;
+
   extensions::WebViewRendererState* renderer_state =
       extensions::WebViewRendererState::GetInstance();
   std::string partition_id;
@@ -153,12 +168,16 @@ bool IsPluginLoadingAccessibleResourceInWebView(
 PluginInfoHostImpl::Context::Context(int render_process_id, Profile* profile)
     : render_process_id_(render_process_id),
       resource_context_(profile->GetResourceContext()),
-#if BUILDFLAG(ENABLE_EXTENSIONS)
-      extension_registry_(extensions::ExtensionRegistry::Get(profile)),
-#endif
       host_content_settings_map_(
           HostContentSettingsMapFactory::GetForProfile(profile)),
       plugin_prefs_(PluginPrefs::GetForProfile(profile)) {
+#if BUILDFLAG(ENABLE_EXTENSIONS)
+#if BUILDFLAG(ENABLE_CEF)
+  if (extensions::ExtensionsEnabled())
+#endif
+    extension_registry_ = extensions::ExtensionRegistry::Get(profile);
+#endif
+
   allow_outdated_plugins_.Init(prefs::kPluginsAllowOutdated,
                                profile->GetPrefs());
   allow_outdated_plugins_.MoveToThread(
@@ -325,6 +344,14 @@ void PluginInfoHostImpl::Context::DecidePluginStatus(
     PluginMetadata::SecurityStatus security_status,
     const std::string& plugin_identifier,
     chrome::mojom::PluginStatus* status) const {
+#if BUILDFLAG(ENABLE_CEF)
+  // Don't override the user decision.
+  if (*status == chrome::mojom::PluginStatus::kBlocked ||
+      *status == chrome::mojom::PluginStatus::kDisabled) {
+    return;
+  }
+#endif
+
   if (security_status == PluginMetadata::SECURITY_STATUS_FULLY_TRUSTED) {
     *status = chrome::mojom::PluginStatus::kAllowed;
     return;
@@ -450,16 +477,36 @@ bool PluginInfoHostImpl::Context::FindEnabledPlugin(
     return false;
   }
 
+  const bool is_main_frame =
+      main_frame_origin.IsSameOriginWith(url::Origin::Create(url));
+
+#if BUILDFLAG(ENABLE_CEF)
+  CefPluginServiceFilter* filter = static_cast<CefPluginServiceFilter*>(
+      PluginService::GetInstance()->GetFilter());
+  DCHECK(filter);
+
+  size_t i = 0;
+  for (; i < matching_plugins.size(); ++i) {
+    if (filter->IsPluginAvailable(render_process_id_, render_frame_id,
+                                  resource_context_, url, is_main_frame,
+                                  main_frame_origin, &matching_plugins[i],
+                                  status)) {
+      break;
+    }
+  }
+#else  // !BUILDFLAG(ENABLE_CEF)
   content::PluginServiceFilter* filter =
       PluginService::GetInstance()->GetFilter();
   size_t i = 0;
   for (; i < matching_plugins.size(); ++i) {
     if (!filter || filter->IsPluginAvailable(
                        render_process_id_, render_frame_id, resource_context_,
-                       url, main_frame_origin, &matching_plugins[i])) {
+                       url, is_main_frame, main_frame_origin,
+                       &matching_plugins[i])) {
       break;
     }
   }
+#endif  // !BUILDFLAG(ENABLE_CEF)
 
   // If we broke out of the loop, we have found an enabled plugin.
   bool enabled = i < matching_plugins.size();
diff --git chrome/renderer/chrome_content_renderer_client.cc chrome/renderer/chrome_content_renderer_client.cc
index 5dc888bfb2df..297737be682e 100644
--- chrome/renderer/chrome_content_renderer_client.cc
+++ chrome/renderer/chrome_content_renderer_client.cc
@@ -805,6 +805,7 @@ WebPlugin* ChromeContentRendererClient::CreatePlugin(
 
     if ((status == chrome::mojom::PluginStatus::kUnauthorized ||
          status == chrome::mojom::PluginStatus::kBlocked) &&
+        observer &&
         observer->IsPluginTemporarilyAllowed(identifier)) {
       status = chrome::mojom::PluginStatus::kAllowed;
     }
@@ -992,7 +993,8 @@ WebPlugin* ChromeContentRendererClient::CreatePlugin(
         render_frame->GetRemoteAssociatedInterfaces()->GetInterface(
             &plugin_auth_host);
         plugin_auth_host->BlockedUnauthorizedPlugin(group_name, identifier);
-        observer->DidBlockContentType(content_type, group_name);
+        if (observer)
+          observer->DidBlockContentType(content_type, group_name);
         break;
       }
       case chrome::mojom::PluginStatus::kBlocked: {
@@ -1001,7 +1003,8 @@ WebPlugin* ChromeContentRendererClient::CreatePlugin(
             l10n_util::GetStringFUTF16(IDS_PLUGIN_BLOCKED, group_name));
         placeholder->AllowLoading();
         RenderThread::Get()->RecordAction(UserMetricsAction("Plugin_Blocked"));
-        observer->DidBlockContentType(content_type, group_name);
+        if (observer)
+          observer->DidBlockContentType(content_type, group_name);
         break;
       }
       case chrome::mojom::PluginStatus::kBlockedByPolicy: {
@@ -1011,7 +1014,8 @@ WebPlugin* ChromeContentRendererClient::CreatePlugin(
                                        group_name));
         RenderThread::Get()->RecordAction(
             UserMetricsAction("Plugin_BlockedByPolicy"));
-        observer->DidBlockContentType(content_type, group_name);
+        if (observer)
+          observer->DidBlockContentType(content_type, group_name);
         break;
       }
       case chrome::mojom::PluginStatus::kBlockedNoLoading: {
@@ -1019,7 +1023,8 @@ WebPlugin* ChromeContentRendererClient::CreatePlugin(
             IDR_BLOCKED_PLUGIN_HTML,
             l10n_util::GetStringFUTF16(IDS_PLUGIN_BLOCKED_NO_LOADING,
                                        group_name));
-        observer->DidBlockContentType(content_type, group_name);
+        if (observer)
+          observer->DidBlockContentType(content_type, group_name);
         break;
       }
       case chrome::mojom::PluginStatus::kComponentUpdateRequired: {