diff --git chrome/browser/profiles/profile_manager.cc chrome/browser/profiles/profile_manager.cc
index 4e44716a40f3..1eb4731da1cf 100644
--- chrome/browser/profiles/profile_manager.cc
+++ chrome/browser/profiles/profile_manager.cc
@@ -359,7 +359,7 @@ ProfileManager::ProfileManager(const base::FilePath& user_data_dir)
   registrar_.Add(this, chrome::NOTIFICATION_BROWSER_CLOSE_CANCELLED,
                  content::NotificationService::AllSources());
 
-  if (ProfileShortcutManager::IsFeatureEnabled() && !user_data_dir_.empty())
+  if (!user_data_dir_.empty() && ProfileShortcutManager::IsFeatureEnabled())
     profile_shortcut_manager_ = ProfileShortcutManager::Create(this);
 }
 
diff --git chrome/browser/profiles/profile_manager.h chrome/browser/profiles/profile_manager.h
index 7d02af7f8f60..eb70e533dbfb 100644
--- chrome/browser/profiles/profile_manager.h
+++ chrome/browser/profiles/profile_manager.h
@@ -99,7 +99,7 @@ class ProfileManager : public content::NotificationObserver,
   // acceptable. Returns null if creation of the new profile fails.
   // TODO(bauerb): Migrate calls from other code to GetProfileByPath(), then
   // make this method private.
-  Profile* GetProfile(const base::FilePath& profile_dir);
+  virtual Profile* GetProfile(const base::FilePath& profile_dir);
 
   // Returns total number of profiles available on this machine.
   size_t GetNumberOfProfiles();
@@ -129,7 +129,7 @@ class ProfileManager : public content::NotificationObserver,
 
   // Returns true if the profile pointer is known to point to an existing
   // profile.
-  bool IsValidProfile(const void* profile);
+  virtual bool IsValidProfile(const void* profile);
 
   // Returns the directory where the first created profile is stored,
   // relative to the user data directory currently in use.
@@ -138,7 +138,7 @@ class ProfileManager : public content::NotificationObserver,
   // Get the Profile last used (the Profile to which owns the most recently
   // focused window) with this Chrome build. If no signed profile has been
   // stored in Local State, hand back the Default profile.
-  Profile* GetLastUsedProfile(const base::FilePath& user_data_dir);
+  virtual Profile* GetLastUsedProfile(const base::FilePath& user_data_dir);
 
   // Get the path of the last used profile, or if that's undefined, the default
   // profile.
diff --git chrome/browser/profiles/renderer_updater.cc chrome/browser/profiles/renderer_updater.cc
index 07e6f8d726df..9a3c6b38b8eb 100644
--- chrome/browser/profiles/renderer_updater.cc
+++ chrome/browser/profiles/renderer_updater.cc
@@ -7,6 +7,7 @@
 #include <utility>
 
 #include "base/bind.h"
+#include "cef/libcef/features/features.h"
 #include "chrome/browser/content_settings/host_content_settings_map_factory.h"
 #include "chrome/browser/profiles/profile.h"
 #include "chrome/browser/signin/identity_manager_factory.h"
@@ -67,8 +68,12 @@ void GetGuestViewDefaultContentSettingRules(
 
 RendererUpdater::RendererUpdater(Profile* profile)
     : profile_(profile), identity_manager_observer_(this) {
+#if !BUILDFLAG(ENABLE_CEF)
   identity_manager_ = IdentityManagerFactory::GetForProfile(profile);
   identity_manager_observer_.Add(identity_manager_);
+#else
+  identity_manager_ = nullptr;
+#endif
 #if defined(OS_CHROMEOS)
   oauth2_login_manager_ =
       chromeos::OAuth2LoginManagerFactory::GetForProfile(profile_);
@@ -238,7 +243,7 @@ void RendererUpdater::UpdateRenderer(
           force_google_safesearch_.GetValue(),
           force_youtube_restrict_.GetValue(),
           allowed_domains_for_apps_.GetValue(),
-          identity_manager_->HasPrimaryAccount()
+          identity_manager_ && identity_manager_->HasPrimaryAccount()
               ? cached_variation_ids_header_signed_in_
               : cached_variation_ids_header_));
 }