diff --git chrome/browser/profiles/off_the_record_profile_impl.cc chrome/browser/profiles/off_the_record_profile_impl.cc
index cf4597e671afe..a9693c4e10d8e 100644
--- chrome/browser/profiles/off_the_record_profile_impl.cc
+++ chrome/browser/profiles/off_the_record_profile_impl.cc
@@ -647,7 +647,9 @@ std::unique_ptr<Profile> Profile::CreateOffTheRecordProfile(
 #endif
   if (!profile)
     profile = std::make_unique<OffTheRecordProfileImpl>(parent, otr_profile_id);
-  profile->Init();
+  // With CEF we want to delay initialization.
+  if (!otr_profile_id.IsUniqueForCEF())
+    profile->Init();
   return std::move(profile);
 }
 
diff --git chrome/browser/profiles/profile.cc chrome/browser/profiles/profile.cc
index 4385d5d90f9c8..88aca5519660e 100644
--- chrome/browser/profiles/profile.cc
+++ chrome/browser/profiles/profile.cc
@@ -84,6 +84,7 @@ base::LazyInstance<std::set<content::BrowserContext*>>::Leaky
 
 namespace {
 
+const char kCEFOTRProfileIDPrefix[] = "CEF::BrowserContext";
 const char kDevToolsOTRProfileIDPrefix[] = "Devtools::BrowserContext";
 const char kMediaRouterOTRProfileIDPrefix[] = "MediaRouter::Presentation";
 const char kTestOTRProfileIDPrefix[] = "Test::OTR";
@@ -104,6 +105,8 @@ bool Profile::OTRProfileID::AllowsBrowserWindows() const {
   // DevTools::BrowserContext, MediaRouter::Presentation, and
   // CaptivePortal::Signin are exceptions to this ban.
   if (*this == PrimaryID() ||
+      base::StartsWith(profile_id_, kCEFOTRProfileIDPrefix,
+                       base::CompareCase::SENSITIVE) ||
       base::StartsWith(profile_id_, kDevToolsOTRProfileIDPrefix,
                        base::CompareCase::SENSITIVE) ||
       base::StartsWith(profile_id_, kMediaRouterOTRProfileIDPrefix,
@@ -141,6 +144,16 @@ Profile::OTRProfileID Profile::OTRProfileID::CreateUnique(
       base::Uuid::GenerateRandomV4().AsLowercaseString().c_str()));
 }
 
+// static
+Profile::OTRProfileID Profile::OTRProfileID::CreateUniqueForCEF() {
+  return CreateUnique(kCEFOTRProfileIDPrefix);
+}
+
+bool Profile::OTRProfileID::IsUniqueForCEF() const {
+  return base::StartsWith(profile_id_, kCEFOTRProfileIDPrefix,
+                          base::CompareCase::SENSITIVE);
+}
+
 // static
 Profile::OTRProfileID Profile::OTRProfileID::CreateUniqueForDevTools() {
   return CreateUnique(kDevToolsOTRProfileIDPrefix);
diff --git chrome/browser/profiles/profile.h chrome/browser/profiles/profile.h
index 8e96e47754dc7..c65184775fba7 100644
--- chrome/browser/profiles/profile.h
+++ chrome/browser/profiles/profile.h
@@ -94,6 +94,10 @@ class Profile : public content::BrowserContext {
     // be applicable to run. Please see crbug.com/1098697#c3 for more details.
     static OTRProfileID CreateUnique(const std::string& profile_id_prefix);
 
+    // Creates a unique OTR profile id to be used for CEF browser contexts.
+    static OTRProfileID CreateUniqueForCEF();
+    bool IsUniqueForCEF() const;
+
     // Creates a unique OTR profile id to be used for DevTools browser contexts.
     static OTRProfileID CreateUniqueForDevTools();
 
@@ -506,6 +510,9 @@ class Profile : public content::BrowserContext {
   static Profile* FromJavaObject(const jni_zero::JavaRef<jobject>& obj);
   jni_zero::ScopedJavaLocalRef<jobject> GetJavaObject() const;
 #endif  // BUILDFLAG(IS_ANDROID)
+
+  void NotifyOffTheRecordProfileCreated(Profile* off_the_record);
+
  protected:
   // Creates an OffTheRecordProfile which points to this Profile.
   static std::unique_ptr<Profile> CreateOffTheRecordProfile(
@@ -517,7 +524,6 @@ class Profile : public content::BrowserContext {
   static PrefStore* CreateExtensionPrefStore(Profile*,
                                              bool incognito_pref_store);
 
-  void NotifyOffTheRecordProfileCreated(Profile* off_the_record);
   void NotifyProfileInitializationComplete();
 
   // Returns whether the user has signed in this profile to an account.
diff --git chrome/browser/profiles/profile_impl.cc chrome/browser/profiles/profile_impl.cc
index 3dd5f9818cfa0..7b3e3697f4ce3 100644
--- chrome/browser/profiles/profile_impl.cc
+++ chrome/browser/profiles/profile_impl.cc
@@ -1038,7 +1038,9 @@ Profile* ProfileImpl::GetOffTheRecordProfile(const OTRProfileID& otr_profile_id,
 
   otr_profiles_[otr_profile_id] = std::move(otr_profile);
 
-  NotifyOffTheRecordProfileCreated(raw_otr_profile);
+  // With CEF we want to delay initialization.
+  if (!otr_profile_id.IsUniqueForCEF())
+    NotifyOffTheRecordProfileCreated(raw_otr_profile);
 
   return raw_otr_profile;
 }