diff --git content/browser/child_process_security_policy_impl.cc content/browser/child_process_security_policy_impl.cc
index 2bfca65cd8d13..0a5b7a68fca46 100644
--- content/browser/child_process_security_policy_impl.cc
+++ content/browser/child_process_security_policy_impl.cc
@@ -1860,6 +1860,16 @@ bool ChildProcessSecurityPolicyImpl::CanAccessDataForMaybeOpaqueOrigin(
             // DeclarativeApiTest.PersistRules.
             if (actual_process_lock.matches_scheme(url::kDataScheme))
               return true;
+
+            // Allow other schemes that are non-standard, non-local and WebSafe.
+            if (lock_url.is_valid() &&
+                !lock_url.IsStandard() &&
+                !base::Contains(url::GetLocalSchemes(),
+                                lock_url.scheme_piece()) &&
+                base::Contains(schemes_okay_to_request_in_any_process_,
+                               lock_url.scheme())) {
+              return true;
+            }
           }
 
           // Make an exception to allow most visited tiles to commit in
diff --git content/browser/renderer_host/navigation_request.cc content/browser/renderer_host/navigation_request.cc
index 948ee821dfea0..d63fd2bb9508b 100644
--- content/browser/renderer_host/navigation_request.cc
+++ content/browser/renderer_host/navigation_request.cc
@@ -7281,10 +7281,22 @@ NavigationRequest::GetOriginForURLLoaderFactoryBeforeResponseWithDebugInfo(
   bool use_opaque_origin =
       (sandbox_flags & network::mojom::WebSandboxFlags::kOrigin) ==
       network::mojom::WebSandboxFlags::kOrigin;
+  if (use_opaque_origin) {
+    origin_and_debug_info.second += ", sandbox_flags";
+  }
+
+  if (!origin_and_debug_info.first.GetURL().IsStandard()) {
+    // Always return an opaque origin for non-standard URLs. Otherwise, the
+    // CanAccessDataForOrigin() check may fail for unregistered custom scheme
+    // requests in CEF.
+    use_opaque_origin = true;
+    origin_and_debug_info.second += ", cef_nonstandard";
+  }
+
   if (use_opaque_origin) {
     origin_and_debug_info =
         std::make_pair(origin_and_debug_info.first.DeriveNewOpaqueOrigin(),
-                       origin_and_debug_info.second + ", sandbox_flags");
+                       origin_and_debug_info.second);
   }
 
   return origin_and_debug_info;
@@ -7314,6 +7326,15 @@ NavigationRequest::GetOriginForURLLoaderFactoryAfterResponseWithDebugInfo() {
       GetOriginForURLLoaderFactoryBeforeResponseWithDebugInfo(
           SandboxFlagsToCommit());
 
+  if (origin_with_debug_info.first.opaque() &&
+      origin_with_debug_info.second.find("cef_nonstandard") !=
+          std::string::npos) {
+    // Always return an opaque origin for non-standard URLs. Otherwise, the
+    // below CanAccessDataForOrigin() check may fail for unregistered custom
+    // scheme requests in CEF.
+    return origin_with_debug_info;
+  }
+
   // MHTML documents should commit as an opaque origin. They should not be able
   // to make network request on behalf of the real origin.
   DCHECK(!IsMhtmlOrSubframe() || origin_with_debug_info.first.opaque());