diff --git chrome/browser/download/chrome_download_manager_delegate.cc chrome/browser/download/chrome_download_manager_delegate.cc
index cfcae9fc073be..b8c140692facc 100644
--- chrome/browser/download/chrome_download_manager_delegate.cc
+++ chrome/browser/download/chrome_download_manager_delegate.cc
@@ -30,6 +30,7 @@
 #include "base/task/thread_pool.h"
 #include "base/time/time.h"
 #include "build/build_config.h"
+#include "cef/libcef/features/features.h"
 #include "chrome/browser/browser_process.h"
 #include "chrome/browser/download/bubble/download_bubble_prefs.h"
 #include "chrome/browser/download/download_core_service.h"
@@ -164,6 +165,10 @@
 #endif  // BUILDFLAG(ENABLE_EXTENSIONS)
 #endif  // BUILDFLAG(SAFE_BROWSING_DOWNLOAD_PROTECTION)
 
+#if BUILDFLAG(ENABLE_CEF)
+#include "cef/libcef/browser/download_manager_delegate.h"
+#endif
+
 using content::BrowserThread;
 using content::DownloadManager;
 using download::DownloadItem;
@@ -523,6 +528,11 @@ ChromeDownloadManagerDelegate::ChromeDownloadManagerDelegate(Profile* profile)
   download_dialog_bridge_ = std::make_unique<DownloadDialogBridge>();
   download_message_bridge_ = std::make_unique<DownloadMessageBridge>();
 #endif
+
+#if BUILDFLAG(ENABLE_CEF)
+  cef_delegate_ =
+      cef::DownloadManagerDelegate::Create(profile_->GetDownloadManager());
+#endif
 }
 
 ChromeDownloadManagerDelegate::~ChromeDownloadManagerDelegate() {
@@ -586,6 +596,9 @@ void ChromeDownloadManagerDelegate::Shutdown() {
     download_manager_->RemoveObserver(this);
     download_manager_ = nullptr;
   }
+#if BUILDFLAG(ENABLE_CEF)
+  cef_delegate_.reset();
+#endif
 }
 
 void ChromeDownloadManagerDelegate::OnDownloadCanceledAtShutdown(
@@ -654,6 +667,12 @@ bool ChromeDownloadManagerDelegate::DetermineDownloadTarget(
     ReportPDFLoadStatus(PDFLoadStatus::kTriggeredNoGestureDriveByDownload);
   }
 
+#if BUILDFLAG(ENABLE_CEF)
+  if (cef_delegate_->DetermineDownloadTarget(download, callback)) {
+    return true;
+  }
+#endif
+
   DownloadTargetDeterminer::CompletionCallback target_determined_callback =
       base::BindOnce(&ChromeDownloadManagerDelegate::OnDownloadTargetDetermined,
                      weak_ptr_factory_.GetWeakPtr(), download->GetId(),
@@ -1142,8 +1161,13 @@ void ChromeDownloadManagerDelegate::OpenDownload(DownloadItem* download) {
     return;
   }
 
+
   Browser* browser = chrome::ScopedTabbedBrowserDisplayer(profile_).browser();
-  CHECK(browser && browser->CanSupportWindowFeature(Browser::FEATURE_TABSTRIP));
+  CHECK(browser
+#if !BUILDFLAG(ENABLE_CEF)
+        && browser->CanSupportWindowFeature(Browser::FEATURE_TABSTRIP)
+#endif
+  );
   content::OpenURLParams params(
       net::FilePathToFileURL(download->GetTargetFilePath()),
       content::Referrer(), WindowOpenDisposition::NEW_FOREGROUND_TAB,
diff --git chrome/browser/download/chrome_download_manager_delegate.h chrome/browser/download/chrome_download_manager_delegate.h
index 41db535e5cf9c..015d84cc95b49 100644
--- chrome/browser/download/chrome_download_manager_delegate.h
+++ chrome/browser/download/chrome_download_manager_delegate.h
@@ -19,6 +19,7 @@
 #include "base/task/sequenced_task_runner.h"
 #include "base/unguessable_token.h"
 #include "build/build_config.h"
+#include "cef/libcef/features/features.h"
 #include "chrome/browser/download/download_completion_blocker.h"
 #include "chrome/browser/download/download_target_determiner_delegate.h"
 #include "components/download/public/common/download_danger_type.h"
@@ -58,6 +59,12 @@ class CrxInstallError;
 }
 #endif
 
+#if BUILDFLAG(ENABLE_CEF)
+namespace cef {
+class DownloadManagerDelegate;
+}
+#endif
+
 // This is the Chrome side helper for the download system.
 class ChromeDownloadManagerDelegate
     : public content::DownloadManagerDelegate,
@@ -406,6 +413,10 @@ class ChromeDownloadManagerDelegate
   // Whether a file picker dialog is showing.
   bool is_file_picker_showing_;
 
+#if BUILDFLAG(ENABLE_CEF)
+  std::unique_ptr<cef::DownloadManagerDelegate> cef_delegate_;
+#endif
+
   base::WeakPtrFactory<ChromeDownloadManagerDelegate> weak_ptr_factory_{this};
 };