diff --git chrome/browser/profiles/off_the_record_profile_impl.cc chrome/browser/profiles/off_the_record_profile_impl.cc
index 43431d7a42fe5..a440d7732f7dd 100644
--- chrome/browser/profiles/off_the_record_profile_impl.cc
+++ chrome/browser/profiles/off_the_record_profile_impl.cc
@@ -659,7 +659,9 @@ std::unique_ptr<Profile> Profile::CreateOffTheRecordProfile(
 #endif
   if (!profile)
     profile = std::make_unique<OffTheRecordProfileImpl>(parent, otr_profile_id);
-  profile->Init();
+  // With CEF we want to delay initialization.
+  if (!otr_profile_id.IsUniqueForCEF())
+    profile->Init();
   return std::move(profile);
 }
 
diff --git chrome/browser/profiles/profile.cc chrome/browser/profiles/profile.cc
index d035eb9f2bea7..0ff6726604022 100644
--- chrome/browser/profiles/profile.cc
+++ chrome/browser/profiles/profile.cc
@@ -84,6 +84,7 @@ base::LazyInstance<std::set<content::BrowserContext*>>::Leaky
 
 namespace {
 
+const char kCEFOTRProfileIDPrefix[] = "CEF::BrowserContext";
 const char kDevToolsOTRProfileIDPrefix[] = "Devtools::BrowserContext";
 const char kMediaRouterOTRProfileIDPrefix[] = "MediaRouter::Presentation";
 const char kTestOTRProfileIDPrefix[] = "Test::OTR";
@@ -104,6 +105,8 @@ bool Profile::OTRProfileID::AllowsBrowserWindows() const {
   // DevTools::BrowserContext, MediaRouter::Presentation, and
   // CaptivePortal::Signin are exceptions to this ban.
   if (*this == PrimaryID() ||
+      base::StartsWith(profile_id_, kCEFOTRProfileIDPrefix,
+                       base::CompareCase::SENSITIVE) ||
       base::StartsWith(profile_id_, kDevToolsOTRProfileIDPrefix,
                        base::CompareCase::SENSITIVE) ||
       base::StartsWith(profile_id_, kMediaRouterOTRProfileIDPrefix,
@@ -141,6 +144,16 @@ Profile::OTRProfileID Profile::OTRProfileID::CreateUnique(
       base::GUID::GenerateRandomV4().AsLowercaseString().c_str()));
 }
 
+// static
+Profile::OTRProfileID Profile::OTRProfileID::CreateUniqueForCEF() {
+  return CreateUnique(kCEFOTRProfileIDPrefix);
+}
+
+bool Profile::OTRProfileID::IsUniqueForCEF() const {
+  return base::StartsWith(profile_id_, kCEFOTRProfileIDPrefix,
+                          base::CompareCase::SENSITIVE);
+}
+
 // static
 Profile::OTRProfileID Profile::OTRProfileID::CreateUniqueForDevTools() {
   return CreateUnique(kDevToolsOTRProfileIDPrefix);
diff --git chrome/browser/profiles/profile.h chrome/browser/profiles/profile.h
index 1e6a22d95a53f..6ec4182bfc5e7 100644
--- chrome/browser/profiles/profile.h
+++ chrome/browser/profiles/profile.h
@@ -99,6 +99,10 @@ class Profile : public content::BrowserContext {
     // be applicable to run. Please see crbug.com/1098697#c3 for more details.
     static OTRProfileID CreateUnique(const std::string& profile_id_prefix);
 
+    // Creates a unique OTR profile id to be used for CEF browser contexts.
+    static OTRProfileID CreateUniqueForCEF();
+    bool IsUniqueForCEF() const;
+
     // Creates a unique OTR profile id to be used for DevTools browser contexts.
     static OTRProfileID CreateUniqueForDevTools();
 
@@ -494,6 +498,8 @@ class Profile : public content::BrowserContext {
 
   base::WeakPtr<Profile> GetWeakPtr();
 
+  void NotifyOffTheRecordProfileCreated(Profile* off_the_record);
+
  protected:
   // Creates an OffTheRecordProfile which points to this Profile.
   static std::unique_ptr<Profile> CreateOffTheRecordProfile(
@@ -505,7 +511,6 @@ class Profile : public content::BrowserContext {
   static PrefStore* CreateExtensionPrefStore(Profile*,
                                              bool incognito_pref_store);
 
-  void NotifyOffTheRecordProfileCreated(Profile* off_the_record);
   void NotifyProfileInitializationComplete();
 
   // Returns whether the user has signed in this profile to an account.
diff --git chrome/browser/profiles/profile_impl.cc chrome/browser/profiles/profile_impl.cc
index 3ee6b902b6bc2..6416146fba8af 100644
--- chrome/browser/profiles/profile_impl.cc
+++ chrome/browser/profiles/profile_impl.cc
@@ -1015,7 +1015,9 @@ Profile* ProfileImpl::GetOffTheRecordProfile(const OTRProfileID& otr_profile_id,
 
   otr_profiles_[otr_profile_id] = std::move(otr_profile);
 
-  NotifyOffTheRecordProfileCreated(raw_otr_profile);
+  // With CEF we want to delay initialization.
+  if (!otr_profile_id.IsUniqueForCEF())
+    NotifyOffTheRecordProfileCreated(raw_otr_profile);
 
   return raw_otr_profile;
 }
diff --git chrome/browser/profiles/profile_manager.cc chrome/browser/profiles/profile_manager.cc
index eab4bc302ef7d..9ed7d61345263 100644
--- chrome/browser/profiles/profile_manager.cc
+++ chrome/browser/profiles/profile_manager.cc
@@ -392,7 +392,7 @@ ProfileManager::ProfileManager(const base::FilePath& user_data_dir)
                           base::Unretained(this)));
 #endif
 
-  if (ProfileShortcutManager::IsFeatureEnabled() && !user_data_dir_.empty())
+  if (!user_data_dir_.empty() && ProfileShortcutManager::IsFeatureEnabled())
     profile_shortcut_manager_ = ProfileShortcutManager::Create(this);
 
   zombie_metrics_timer_.Start(FROM_HERE, base::Minutes(30), this,
diff --git chrome/browser/profiles/profile_manager.h chrome/browser/profiles/profile_manager.h
index c3626f110e6fb..c7d70d32d8f37 100644
--- chrome/browser/profiles/profile_manager.h
+++ chrome/browser/profiles/profile_manager.h
@@ -130,7 +130,7 @@ class ProfileManager : public Profile::Delegate {
   // acceptable. Returns nullptr if loading the new profile fails.
   // TODO(bauerb): Migrate calls from other code to `GetProfileByPath()`, then
   // make this method private.
-  Profile* GetProfile(const base::FilePath& profile_dir);
+  virtual Profile* GetProfile(const base::FilePath& profile_dir);
 
   // Returns regular or off-the-record profile given its profile key.
   static Profile* GetProfileFromProfileKey(ProfileKey* profile_key);
@@ -171,7 +171,7 @@ class ProfileManager : public Profile::Delegate {
 
   // Returns true if the profile pointer is known to point to an existing
   // profile.
-  bool IsValidProfile(const void* profile);
+  virtual bool IsValidProfile(const void* profile);
 
   // Returns the directory where the first created profile is stored,
   // relative to the user data directory currently in use.
diff --git chrome/browser/profiles/renderer_updater.cc chrome/browser/profiles/renderer_updater.cc
index b3cf2ad8d367b..431b44e39de40 100644
--- chrome/browser/profiles/renderer_updater.cc
+++ chrome/browser/profiles/renderer_updater.cc
@@ -8,6 +8,7 @@
 
 #include "base/functional/bind.h"
 #include "build/chromeos_buildflags.h"
+#include "cef/libcef/features/runtime.h"
 #include "chrome/browser/content_settings/content_settings_manager_delegate.h"
 #include "chrome/browser/content_settings/host_content_settings_map_factory.h"
 #include "chrome/browser/profiles/profile.h"
@@ -36,8 +37,10 @@ RendererUpdater::RendererUpdater(Profile* profile)
     : profile_(profile),
       is_off_the_record_(profile_->IsOffTheRecord()),
       original_profile_(profile->GetOriginalProfile()) {
+  if (!cef::IsAlloyRuntimeEnabled()) {
   identity_manager_observation_.Observe(
       IdentityManagerFactory::GetForProfile(original_profile_));
+  }
 
 #if BUILDFLAG(IS_CHROMEOS_ASH)
   oauth2_login_manager_ =