diff --git chrome/browser/download/chrome_download_manager_delegate.cc chrome/browser/download/chrome_download_manager_delegate.cc
index f6cdc397b51cb..69847175527da 100644
--- chrome/browser/download/chrome_download_manager_delegate.cc
+++ chrome/browser/download/chrome_download_manager_delegate.cc
@@ -31,6 +31,7 @@
 #include "base/time/time.h"
 #include "build/build_config.h"
 #include "build/chromeos_buildflags.h"
+#include "cef/libcef/features/features.h"
 #include "chrome/browser/browser_process.h"
 #include "chrome/browser/download/bubble/download_bubble_prefs.h"
 #include "chrome/browser/download/download_core_service.h"
@@ -158,6 +159,10 @@
 #include "chrome/browser/ash/policy/skyvault/skyvault_rename_handler.h"
 #endif
 
+#if BUILDFLAG(ENABLE_CEF)
+#include "cef/libcef/browser/download_manager_delegate.h"
+#endif
+
 using content::BrowserThread;
 using content::DownloadManager;
 using download::DownloadItem;
@@ -519,6 +524,11 @@ ChromeDownloadManagerDelegate::ChromeDownloadManagerDelegate(Profile* profile)
   download_dialog_bridge_ = std::make_unique<DownloadDialogBridge>();
   download_message_bridge_ = std::make_unique<DownloadMessageBridge>();
 #endif
+
+#if BUILDFLAG(ENABLE_CEF)
+  cef_delegate_ =
+      cef::DownloadManagerDelegate::Create(profile_->GetDownloadManager());
+#endif
 }
 
 ChromeDownloadManagerDelegate::~ChromeDownloadManagerDelegate() {
@@ -578,6 +588,9 @@ void ChromeDownloadManagerDelegate::Shutdown() {
     download_manager_->RemoveObserver(this);
     download_manager_ = nullptr;
   }
+#if BUILDFLAG(ENABLE_CEF)
+  cef_delegate_.reset();
+#endif
 }
 
 void ChromeDownloadManagerDelegate::OnDownloadCanceledAtShutdown(
@@ -646,6 +659,12 @@ bool ChromeDownloadManagerDelegate::DetermineDownloadTarget(
     ReportPDFLoadStatus(PDFLoadStatus::kTriggeredNoGestureDriveByDownload);
   }
 
+#if BUILDFLAG(ENABLE_CEF)
+  if (cef_delegate_->DetermineDownloadTarget(download, callback)) {
+    return true;
+  }
+#endif
+
   DownloadTargetDeterminer::CompletionCallback target_determined_callback =
       base::BindOnce(&ChromeDownloadManagerDelegate::OnDownloadTargetDetermined,
                      weak_ptr_factory_.GetWeakPtr(), download->GetId(),
@@ -1067,8 +1086,11 @@ void ChromeDownloadManagerDelegate::OpenDownload(DownloadItem* download) {
   Browser* browser =
       web_contents ? chrome::FindBrowserWithTab(web_contents) : nullptr;
   std::unique_ptr<chrome::ScopedTabbedBrowserDisplayer> browser_displayer;
-  if (!browser ||
-      !browser->CanSupportWindowFeature(Browser::FEATURE_TABSTRIP)) {
+  if (!browser
+#if !BUILDFLAG(ENABLE_CEF)
+      || !browser->CanSupportWindowFeature(Browser::FEATURE_TABSTRIP)
+#endif
+    ) {
     browser_displayer =
         std::make_unique<chrome::ScopedTabbedBrowserDisplayer>(profile_);
     browser = browser_displayer->browser();
diff --git chrome/browser/download/chrome_download_manager_delegate.h chrome/browser/download/chrome_download_manager_delegate.h
index 32d23a0c98061..be6a99a33bdeb 100644
--- chrome/browser/download/chrome_download_manager_delegate.h
+++ chrome/browser/download/chrome_download_manager_delegate.h
@@ -19,6 +19,7 @@
 #include "base/task/sequenced_task_runner.h"
 #include "base/unguessable_token.h"
 #include "build/build_config.h"
+#include "cef/libcef/features/features.h"
 #include "chrome/browser/download/download_completion_blocker.h"
 #include "chrome/browser/download/download_target_determiner_delegate.h"
 #include "components/download/public/common/download_danger_type.h"
@@ -57,6 +58,12 @@ class CrxInstallError;
 }
 #endif
 
+#if BUILDFLAG(ENABLE_CEF)
+namespace cef {
+class DownloadManagerDelegate;
+}
+#endif
+
 // This is the Chrome side helper for the download system.
 class ChromeDownloadManagerDelegate
     : public content::DownloadManagerDelegate,
@@ -393,6 +400,10 @@ class ChromeDownloadManagerDelegate
   // Whether a file picker dialog is showing.
   bool is_file_picker_showing_;
 
+#if BUILDFLAG(ENABLE_CEF)
+  std::unique_ptr<cef::DownloadManagerDelegate> cef_delegate_;
+#endif
+
   base::WeakPtrFactory<ChromeDownloadManagerDelegate> weak_ptr_factory_{this};
 };