diff --git chrome/browser/feedback/system_logs/log_sources/chrome_internal_log_source.cc chrome/browser/feedback/system_logs/log_sources/chrome_internal_log_source.cc
index 16c370e6d9759..7fc6d74075dd4 100644
--- chrome/browser/feedback/system_logs/log_sources/chrome_internal_log_source.cc
+++ chrome/browser/feedback/system_logs/log_sources/chrome_internal_log_source.cc
@@ -20,10 +20,12 @@
 #include "base/strings/string_util.h"
 #include "base/system/sys_info.h"
 #include "base/task/thread_pool.h"
+#include "base/threading/thread_restrictions.h"
 #include "base/time/time.h"
 #include "build/branding_buildflags.h"
 #include "build/build_config.h"
 #include "build/chromeos_buildflags.h"
+#include "cef/libcef/features/runtime.h"
 #include "chrome/browser/browser_process.h"
 #include "chrome/browser/extensions/chrome_content_browser_client_extensions_part.h"
 #include "chrome/browser/google/google_brand.h"
@@ -422,7 +424,15 @@ void ChromeInternalLogSource::Fetch(SysLogsSourceCallback callback) {
   response->emplace(kOsVersionTag, os_version);
 #endif
 
+#if BUILDFLAG(ENABLE_ALLOY_BOOTSTRAP)
+  if (!cef::IsAlloyRuntimeEnabled()) {
+#endif
+  // Avoid loading ProfileSyncServiceFactory which depends on a lot of
+  // unnecessary Chrome-specific factories.
   PopulateSyncLogs(response.get());
+#if BUILDFLAG(ENABLE_ALLOY_BOOTSTRAP)
+  }
+#endif
   PopulateExtensionInfoLogs(response.get());
   PopulatePowerApiLogs(response.get());
 #if BUILDFLAG(IS_WIN)
@@ -510,8 +520,14 @@ void ChromeInternalLogSource::PopulateExtensionInfoLogs(
   if (!profile)
     return;
 
+  // May be nullptr if using CEF Alloy with extensions disabled.
   extensions::ExtensionRegistry* extension_registry =
       extensions::ExtensionRegistry::Get(profile);
+#if BUILDFLAG(ENABLE_ALLOY_BOOTSTRAP)
+  if (!extension_registry)
+    return;
+#endif
+
   std::string extensions_list;
   for (const scoped_refptr<const extensions::Extension>& extension :
        extension_registry->enabled_extensions()) {
@@ -612,6 +628,8 @@ void ChromeInternalLogSource::PopulateOnboardingTime(
 #if BUILDFLAG(IS_WIN)
 void ChromeInternalLogSource::PopulateUsbKeyboardDetected(
     SystemLogsResponse* response) {
+  // The below call may result in some DLLs being loaded.
+  base::ScopedAllowBlockingForTesting allow_blocking;
   std::string reason;
   bool result =
       base::win::IsKeyboardPresentOnSlate(ui::GetHiddenWindow(), &reason);
diff --git chrome/browser/memory_details.cc chrome/browser/memory_details.cc
index 362542c0af479..1841cbe14d5b6 100644
--- chrome/browser/memory_details.cc
+++ chrome/browser/memory_details.cc
@@ -17,6 +17,7 @@
 #include "base/strings/utf_string_conversions.h"
 #include "base/task/thread_pool.h"
 #include "build/build_config.h"
+#include "cef/libcef/features/features.h"
 #include "chrome/browser/profiles/profile.h"
 #include "components/nacl/common/nacl_process_type.h"
 #include "components/strings/grit/components_strings.h"
@@ -298,9 +299,15 @@ void MemoryDetails::CollectChildInfoOnUIThread() {
                 render_process_host->GetBrowserContext())) {
       content::BrowserContext* context =
           render_process_host->GetBrowserContext();
+
+      // May be nullptr if using CEF Alloy with extensions disabled.
       extensions::ExtensionRegistry* extension_registry =
           extensions::ExtensionRegistry::Get(context);
+#if BUILDFLAG(ENABLE_ALLOY_BOOTSTRAP)
+      if (extension_registry) {
+#else
       DCHECK(extension_registry);
+#endif
       extension_set = &extension_registry->enabled_extensions();
       extensions::ProcessMap* process_map =
           extensions::ProcessMap::Get(context);
@@ -316,6 +323,9 @@ void MemoryDetails::CollectChildInfoOnUIThread() {
           process.renderer_type = ProcessMemoryInformation::RENDERER_EXTENSION;
         }
       }
+#if BUILDFLAG(ENABLE_ALLOY_BOOTSTRAP)
+      }
+#endif
     }
 #endif