diff --git a/patch/patch.cfg b/patch/patch.cfg
index b8d7a06ec..76748ee52 100644
--- a/patch/patch.cfg
+++ b/patch/patch.cfg
@@ -247,6 +247,9 @@ patches = [
     # Check RenderProcessHostImpl's |browser_context_| member before re-
     # initializing the channel from RPHI::ProcessDied.
     # https://bitbucket.org/chromiumembedded/cef/issues/2096
+    #
+    # Don't create a "databases" directory when cache_path is empty.
+    # https://bitbucket.org/chromiumembedded/cef/issues/2289
     'name': 'storage_partition_1973',
   },
   {
diff --git a/patch/patches/storage_partition_1973.patch b/patch/patches/storage_partition_1973.patch
index 62619d9bd..0b8a2d5dc 100644
--- a/patch/patches/storage_partition_1973.patch
+++ b/patch/patches/storage_partition_1973.patch
@@ -59,11 +59,15 @@ index 13d802fa72cd..a2d34d1d72eb 100644
        partition->GetBluetoothAllowedDevicesMap();
    return allowed_devices_map->GetOrCreateAllowedDevices(GetOrigin());
 diff --git content/browser/browser_context.cc content/browser/browser_context.cc
-index 42b002908c3b..f7d9c3933090 100644
+index 42b002908c3b..6787b9ed35b7 100644
 --- content/browser/browser_context.cc
 +++ content/browser/browser_context.cc
-@@ -125,7 +125,14 @@ StoragePartition* GetStoragePartitionFromConfig(
-   if (browser_context->IsOffTheRecord())
+@@ -122,10 +122,17 @@ StoragePartition* GetStoragePartitionFromConfig(
+   StoragePartitionImplMap* partition_map =
+       GetStoragePartitionMap(browser_context);
+ 
+-  if (browser_context->IsOffTheRecord())
++  if (browser_context->IsOffTheRecord() || browser_context->GetPath().empty())
      in_memory = true;
  
 -  return partition_map->Get(partition_domain, partition_name, in_memory);
@@ -669,3 +673,16 @@ index cf270b894186..1f95c9c3b023 100644
   protected:
    virtual ~StoragePartition() {}
  };
+diff --git storage/browser/database/database_tracker.cc storage/browser/database/database_tracker.cc
+index 86fb9f41fc71..7a8be02473a3 100644
+--- storage/browser/database/database_tracker.cc
++++ storage/browser/database/database_tracker.cc
+@@ -495,7 +495,7 @@ bool DatabaseTracker::LazyInit() {
+     meta_table_.reset(new sql::MetaTable());
+ 
+     is_initialized_ =
+-        base::CreateDirectory(db_dir_) &&
++        (is_incognito_ ? true : base::CreateDirectory(db_dir_)) &&
+         (db_->is_open() ||
+          (is_incognito_ ? db_->OpenInMemory() :
+           db_->Open(kTrackerDatabaseFullPath))) &&
diff --git a/tests/shared/browser/client_app_browser.cc b/tests/shared/browser/client_app_browser.cc
index d688ff8f0..fe2f2caee 100644
--- a/tests/shared/browser/client_app_browser.cc
+++ b/tests/shared/browser/client_app_browser.cc
@@ -48,6 +48,12 @@ void ClientAppBrowser::OnBeforeCommandLineProcessing(
       command_line->AppendSwitchWithValue("top-chrome-md", "non-material");
     }
 
+    if (!command_line->HasSwitch(switches::kCachePath) &&
+        !command_line->HasSwitch("disable-gpu-shader-disk-cache")) {
+      // Don't create a "GPUCache" directory when cache-path is unspecified.
+      command_line->AppendSwitch("disable-gpu-shader-disk-cache");
+    }
+
     DelegateSet::iterator it = delegates_.begin();
     for (; it != delegates_.end(); ++it)
       (*it)->OnBeforeCommandLineProcessing(this, command_line);