diff --git a/libcef/browser/main_runner.cc b/libcef/browser/main_runner.cc
index 3dbf759ab..32a442961 100644
--- a/libcef/browser/main_runner.cc
+++ b/libcef/browser/main_runner.cc
@@ -181,12 +181,20 @@ class CefUIThread : public base::PlatformThread::Delegate {
 
     runner_->RunMessageLoop();
 
-    browser_runner_->Shutdown();
-    browser_runner_.reset();
+    // Stop may be called before InitializeBrowserRunner if
+    // content::ContentMainRun was not successful (for example, due to process
+    // singleton relaunch).
+    if (browser_runner_) {
+      browser_runner_->Shutdown();
+      browser_runner_.reset();
+    }
 
+    // This will be a no-op if there is no BrowserTaskExecutor.
     content::BrowserTaskExecutor::Shutdown();
 
-    std::move(shutdown_callback_).Run();
+    if (!shutdown_callback_.is_null()) {
+      std::move(shutdown_callback_).Run();
+    }
 
     // Run exit callbacks on the UI thread to avoid sequence check failures.
     base::AtExitManager::ProcessCallbacksNow();
@@ -433,6 +441,11 @@ int CefMainRunner::ContentMainRun(bool* initialized,
                int* exit_code) {
               runner->main_delegate_->BeforeUIThreadInitialize();
               *exit_code = content::ContentMainRun(runner->main_runner_.get());
+
+              if (*exit_code != content::RESULT_CODE_NORMAL_EXIT) {
+                runner->FinishShutdownOnUIThread();
+              }
+
               event->Signal();
             },
             base::Unretained(this), base::Unretained(&uithread_startup_event),
@@ -444,6 +457,13 @@ int CefMainRunner::ContentMainRun(bool* initialized,
 
     // We need to wait until content::ContentMainRun has finished.
     uithread_startup_event.Wait();
+
+    if (exit_code != content::RESULT_CODE_NORMAL_EXIT) {
+      // content::ContentMainRun was not successful (for example, due to process
+      // singleton relaunch). Stop the UI thread and block until done.
+      ui_thread_->Stop();
+      ui_thread_.reset();
+    }
   } else {
     *initialized = true;
     main_delegate_->BeforeUIThreadInitialize();
diff --git a/libcef/common/chrome/chrome_main_runner_delegate.cc b/libcef/common/chrome/chrome_main_runner_delegate.cc
index ce44e62e6..c639e1f60 100644
--- a/libcef/common/chrome/chrome_main_runner_delegate.cc
+++ b/libcef/common/chrome/chrome_main_runner_delegate.cc
@@ -58,6 +58,11 @@ void ChromeMainRunnerDelegate::BeforeMainThreadRun(
 
 void ChromeMainRunnerDelegate::BeforeMainMessageLoopRun(
     base::RunLoop* run_loop) {
+  // May be nullptr if content::ContentMainRun exits early.
+  if (!g_browser_process) {
+    return;
+  }
+
   // The ScopedKeepAlive instance triggers shutdown logic when released on the
   // UI thread before terminating the message loop (e.g. from CefQuitMessageLoop
   // or FinishShutdownOnUIThread when running with multi-threaded message loop).
@@ -67,12 +72,17 @@ void ChromeMainRunnerDelegate::BeforeMainMessageLoopRun(
   // The QuitClosure will be executed from BrowserProcessImpl::Unpin() via
   // KeepAliveRegistry when the last ScopedKeepAlive is released.
   // ScopedKeepAlives are also held by Browser objects.
-  DCHECK(g_browser_process);
   static_cast<BrowserProcessImpl*>(g_browser_process)
       ->SetQuitClosure(run_loop->QuitClosure());
 }
 
 bool ChromeMainRunnerDelegate::HandleMainMessageLoopQuit() {
+  // May be nullptr if content::ContentMainRun exits early.
+  if (!g_browser_process) {
+    // Proceed with direct execution of the QuitClosure().
+    return false;
+  }
+
   // May be called multiple times. See comments in RunMainMessageLoopBefore.
   keep_alive_.reset();
 
diff --git a/tests/cefclient/browser/root_window_views.cc b/tests/cefclient/browser/root_window_views.cc
index d2553665d..db85d63a5 100644
--- a/tests/cefclient/browser/root_window_views.cc
+++ b/tests/cefclient/browser/root_window_views.cc
@@ -58,8 +58,20 @@ void RootWindowViews::Init(RootWindow::Delegate* delegate,
   CreateClientHandler(config_->url);
   initialized_ = true;
 
-  // Continue initialization on the UI thread.
-  InitOnUIThread(settings, delegate_->GetRequestContext(this));
+  if (!CURRENTLY_ON_MAIN_THREAD()) {
+    // Execute GetRequestContext() on the main thread.
+    MAIN_POST_CLOSURE(base::BindOnce(
+        [](scoped_refptr<RootWindowViews> self,
+           const CefBrowserSettings& settings) {
+          // Continue initialization on the UI thread.
+          self->InitOnUIThread(settings,
+                               self->delegate_->GetRequestContext(self.get()));
+        },
+        scoped_refptr<RootWindowViews>(this), settings));
+  } else {
+    // Continue initialization on the UI thread.
+    InitOnUIThread(settings, delegate_->GetRequestContext(this));
+  }
 }
 
 void RootWindowViews::InitAsPopup(RootWindow::Delegate* delegate,