diff --git a/cmake/cef_variables.cmake.in b/cmake/cef_variables.cmake.in
index 8e7c18544..2dced947c 100644
--- a/cmake/cef_variables.cmake.in
+++ b/cmake/cef_variables.cmake.in
@@ -491,6 +491,9 @@ if(OS_WINDOWS)
       PSAPI_VERSION=1   # Required by cef_sandbox.lib
       CEF_USE_SANDBOX   # Used by apps to test if the sandbox is enabled
       )
+    list(APPEND CEF_COMPILER_DEFINES_DEBUG
+      _HAS_ITERATOR_DEBUGGING=0   # Disable iterator debugging
+      )
 
     # Libraries required by cef_sandbox.lib.
     set(CEF_SANDBOX_STANDARD_LIBS
diff --git a/tools/gn_args.py b/tools/gn_args.py
index 7d07f4569..2b277cdf5 100644
--- a/tools/gn_args.py
+++ b/tools/gn_args.py
@@ -480,10 +480,6 @@ def GetConfigArgsSandbox(platform, args, is_debug, cpu):
       'is_cef_sandbox_build': True,
   }
 
-  if is_debug:
-    # Enable iterator debugging (_ITERATOR_DEBUG_LEVEL=2).
-    add_args['enable_iterator_debugging'] = True
-
   if platform == 'windows':
     # Avoid Debug build linker errors caused by custom libc++.
     add_args['use_custom_libcxx'] = False